Bioactive monoterpene indole alkaloids from Nauclea officinalis.
Animals
Anti-HIV Agents
/ chemistry
Anti-Inflammatory Agents, Non-Steroidal
/ chemistry
Dose-Response Relationship, Drug
HIV-1
/ drug effects
Indole Alkaloids
/ chemistry
Lipopolysaccharides
/ antagonists & inhibitors
Mice
Microbial Sensitivity Tests
Molecular Structure
Monoterpenes
/ chemistry
Nitric Oxide
/ antagonists & inhibitors
RAW 264.7 Cells
Rubiaceae
/ chemistry
Structure-Activity Relationship
Anti-HIV-1 activities
Monoterpene indole alkaloids
Nauclea officinalis
Naucleaoffines A and B
Nitric oxide production inhibition
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
04
06
2018
revised:
07
10
2018
accepted:
09
10
2018
pubmed:
20
10
2018
medline:
4
12
2019
entrez:
20
10
2018
Statut:
ppublish
Résumé
Two new monoterpene indole alkaloids, naucleaoffines A (1) and B (2), together with six known alkaloids (3-8), were isolated from the stems and leaves of Nauclea officinalis. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. All isolated compounds were evaluated for their anti-inflammatory activities and anti-HIV-1 activities. Compounds 1-8 exhibited significant inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with IC
Identifiants
pubmed: 30339860
pii: S0045-2068(18)30546-7
doi: 10.1016/j.bioorg.2018.10.013
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Anti-Inflammatory Agents, Non-Steroidal
0
Indole Alkaloids
0
Lipopolysaccharides
0
Monoterpenes
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-5Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.