ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
30
05
2018
accepted:
26
09
2018
revised:
10
09
2018
pubmed:
21
10
2018
medline:
2
10
2020
entrez:
21
10
2018
Statut:
ppublish
Résumé
ABIN-1 (encoded by the gene Tnip1) is a ubiquitin-binding protein that can interact with ubiquitin-editing enzyme A20 (encoded by the gene TNFAIP3) to restrain the activation of necroptosis and NF-κB activation. Genetic variants in the genes Tnip1 and TNFAIP3 are both strongly associated with susceptibility to autoimmune chronic inflammatory diseases such as psoriasis vulgaris and systemic lupus erythematosus (SLE) in humans. Here we investigated the mechanism by which ABIN-1 regulated innate immune responses. We show that ABIN-1 heterozygosity sensitizes cells to antiviral response by mediating NF-κB-dependent and RIPK1-independent expression of pattern recognition molecules, including TLR3, RIG-I, and MDA5, in MEFs. Furthermore, we demonstrate that increased interaction of ABIN-1 and A20 with prolonged poly(I:C) stimulation of WT cells leads to A20-dependent reduction of ABIN-1 protein. Finally, we show that ABIN-1 heterozygosity sensitizes innate immune response of Abin-1
Identifiants
pubmed: 30341420
doi: 10.1038/s41418-018-0215-3
pii: 10.1038/s41418-018-0215-3
pmc: PMC6748150
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Tnip2 protein, mouse
0
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Ripk1 protein, mouse
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1077-1088Subventions
Organisme : NIA NIH HHS
ID : RF1 AG055521
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS082257
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047231
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106934
Pays : United States
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