Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts.
3T3 Cells
Animals
Cells, Cultured
Dose-Response Relationship, Drug
Down-Regulation
/ drug effects
Extracellular Matrix Proteins
/ genetics
Mice
Osteoblasts
/ drug effects
Phosphate Transport Proteins
/ physiology
Phosphates
/ pharmacology
Receptors, Fibroblast Growth Factor
/ physiology
Signal Transduction
/ drug effects
Calcium
FGFR
MC3T3-E1
Nephronectin
Phosphate
Journal
Calcified tissue international
ISSN: 1432-0827
Titre abrégé: Calcif Tissue Int
Pays: United States
ID NLM: 7905481
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
21
08
2018
accepted:
11
10
2018
pubmed:
21
10
2018
medline:
10
6
2020
entrez:
21
10
2018
Statut:
ppublish
Résumé
Nephronectin (Npnt), an extracellular matrix protein, is known to be a ligand of integrin α8β1, and it has also been known to play critical roles as various organs. In the present study, elevated extracellular inorganic phosphate (Pi) strongly inhibited the expression of Npnt in MC3T3-E1 cells, while the existence of extracellular calcium (Ca) was indispensable for its effect. Furthermore, Pi-induced inhibition of Npnt gene expression was recovered by inhibitors of both sodium-dependent Pi transporter (Pit) and fibroblast growth factor receptors (Fgfrs). These results demonstrated that Npnt gene expression is regulated by extracellular Pi via Pit and Fgfrs.
Identifiants
pubmed: 30341591
doi: 10.1007/s00223-018-0484-3
pii: 10.1007/s00223-018-0484-3
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Npnt protein, mouse
0
Phosphate Transport Proteins
0
Phosphates
0
Receptors, Fibroblast Growth Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM