Anticariogenic efficacy of a saliva biomimetic in head-and-neck cancer patients undergoing radiotherapy.
Caries
Casein phosphopeptide-amorphous calcium phosphate
Demineralization
Head-and-neck radiotherapy
Stannous fluoride
Journal
Australian dental journal
ISSN: 1834-7819
Titre abrégé: Aust Dent J
Pays: Australia
ID NLM: 0370612
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
accepted:
14
10
2018
pubmed:
21
10
2018
medline:
4
12
2019
entrez:
21
10
2018
Statut:
ppublish
Résumé
The aim of this study was to investigate the effect of treatment with the saliva biomimetic, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and SnF Twenty-four participants were randomized into two groups. Both groups used 0.4% SnF Both groups showed significantly reduced resting saliva flow rate (P < 0.001) postradiotherapy. There were no significant differences in flow rates and fluoride concentration between groups. The CPP-ACP group exhibited a significant (P < 0.05) 51% reduction in coronal surface caries progression compared with the placebo group. Resting salivary flow rate was significantly reduced in head-and-neck cancer patients following radiotherapy and use of CPP-ACP with SnF
Sections du résumé
BACKGROUND
The aim of this study was to investigate the effect of treatment with the saliva biomimetic, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and SnF
METHODS
Twenty-four participants were randomized into two groups. Both groups used 0.4% SnF
RESULTS
Both groups showed significantly reduced resting saliva flow rate (P < 0.001) postradiotherapy. There were no significant differences in flow rates and fluoride concentration between groups. The CPP-ACP group exhibited a significant (P < 0.05) 51% reduction in coronal surface caries progression compared with the placebo group.
CONCLUSION
Resting salivary flow rate was significantly reduced in head-and-neck cancer patients following radiotherapy and use of CPP-ACP with SnF
Substances chimiques
Caseins
0
Toothpastes
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-54Subventions
Organisme : National Dental Centre Singapore Research Fund/National Medical Research Council Centre
Pays : International
Organisme : Australian Government, Department of Industry, Innovation and Science
Pays : International
Informations de copyright
© 2018 Australian Dental Association.