Polysaccharides from Laminaria japonica alleviated metabolic syndrome in BALB/c mice by normalizing the gut microbiota.
Gut microbiota
Laminaria japonica
Obesity
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
13
03
2018
revised:
28
09
2018
accepted:
14
10
2018
pubmed:
21
10
2018
medline:
16
1
2019
entrez:
21
10
2018
Statut:
ppublish
Résumé
Polysaccharides from Laminaria japonica (LJPs) are reported to have various functional properties, but the effects and mechanisms of LJPs on obesity and its related diseases are unclear. This study demonstrated that LJPs prevented diet-induced obesity in a mice model, and improved obesity-related parameters, e.g. fat accumulation in the liver and adipose tissues, body composition, lipids profile, and the morphology of the intestine. Such effects were associated with the modulation of the gut microbiota, involving some members of the Bacteroidetes phylum. Changes in the gut microbiota could improve nutrient utilization, increase microbial metabolites production, and thus regulate lipids metabolism in the body. In short, it sought to indicate that L. japonica can be developed as food supplement for the improvement of metabolic syndrome and the human gut health.
Identifiants
pubmed: 30342121
pii: S0141-8130(18)31205-4
doi: 10.1016/j.ijbiomac.2018.10.087
pii:
doi:
Substances chimiques
Fatty Acids
0
Polysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
996-1004Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.