Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus.
Cancer
Endogenous retroviruses, Interferon Regulatory Factor
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
27
07
2018
revised:
01
10
2018
accepted:
01
10
2018
pubmed:
21
10
2018
medline:
30
1
2019
entrez:
21
10
2018
Statut:
ppublish
Résumé
Endogenous retroviruses (ERVs) comprise 10% of the genome, with many of these transcriptionally silenced post early embryogenesis. Several stimuli, including exogenous virus infection and cellular transformation can reactivate ERV expression via a poorly understood mechanism. We identified Interferon Regulatory Factor 1 (IRF-1), a tumor suppressor and an antiviral host factor, as a suppressor of ERV expression. IRF-1 decreased expression of a specific mouse ERV in vitro and in vivo. IRF-3, but not IRF-7, also decreased expression of distinct ERV families, suggesting that suppression of ERVs is a relevant biological function of the IRF family. Given the emerging appreciation of the physiological relevance of ERV expression in cancer, IRF-1-mediated suppression of specific ERVs may contribute to the overall tumor suppressor activity of this host factor.
Identifiants
pubmed: 30342302
pii: S0042-6822(18)30307-6
doi: 10.1016/j.virol.2018.10.003
pmc: PMC6875439
mid: NIHMS1059591
pii:
doi:
Substances chimiques
Interferon Regulatory Factor-1
0
Interferon Regulatory Factor-3
0
Irf1 protein, mouse
0
Irf3 protein, mouse
0
Tumor Suppressor Proteins
0
RNA-Directed DNA Polymerase
EC 2.7.7.49
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
52-60Subventions
Organisme : NCI NIH HHS
ID : R01 CA183593
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA203923
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204231
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK052913
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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