The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease.
Proyecto de biomarcadores y perfiles clínicos personalizados en la enfermedad pulmonar obstructiva crónica (proyecto BIOMEPOC).
Análisis multinivel
Biological markers
COPD
EPOC
Endotipos
Endotypes
Marcadores biológicos
Medicina personalizada
Multilevel analysis
Personalized medicine
Journal
Archivos de bronconeumologia
ISSN: 2173-5751
Titre abrégé: Arch Bronconeumol (Engl Ed)
Pays: Spain
ID NLM: 101777538
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
06
04
2018
revised:
16
07
2018
accepted:
31
07
2018
pubmed:
23
10
2018
medline:
15
5
2020
entrez:
23
10
2018
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) is an entity with a heterogeneous presentation. For this reason, attempts have been made to characterize different phenotypes and endotypes to enable a more individualized approach. The aim of the Biomarkers in COPD (BIOMEPOC) project is to identify useful biomarkers in blood to improve the characterization of patients. Clinical data and blood samples from a group of patients and healthy controls will be analyzed. The project will consist of an exploration phase and a validation phase. Analytical parameters in blood will be determined using standard techniques and certain 'omics' (transcriptomics, proteomics, and metabolomics). The former will be hypothesis-driven, whereas the latter will be exploratory. Finally, a multilevel analysis will be conducted. Currently, 269 patients and 83 controls have been recruited, and sample processing is beginning. Our hope is to use the results to identify new biomarkers that, alone or combined, will allow a better characterization of patients.
Identifiants
pubmed: 30343952
pii: S0300-2896(18)30329-6
doi: 10.1016/j.arbres.2018.07.026
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
93-99Investigateurs
Mireia Admetlló
(M)
Alvar Agustí
(A)
Carlos Alvarez-Martínez
(C)
Esther Barreiro
(E)
Carme Casadevall
(C)
Ferran Casals
(F)
Robert Castelo
(R)
Ady Castro-Acosta
(A)
Rocío Córdova
(R)
Borja G Cosío
(BG)
Rosa Faner
(R)
Laura I Furlong
(LI)
Marian García
(M)
Joaquim Gea
(J)
José G González-García
(JG)
Carmen Hernández-Carcereny
(C)
José Luis López-Campos
(JL)
Eduardo Márquez
(E)
Eduard Monsó
(E)
Concepción Montón
(C)
Miren Josune Ormaza
(MJ)
Alexandre Palou
(A)
Sergi Pascual
(S)
Germán Peces-Barba
(G)
Pau Puigdevall
(P)
Ferran Sanz
(F)
Luis Seijó
(L)
Montserrat Torà
(M)
Yolanda Torralba
(Y)
Carles Vilaplana
(C)
Informations de copyright
Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.