Dietary inflammatory index and incidence of breast cancer in the SUN project.
Breast cancer
Cohort
Dietary inflammatory index
Inflammation
SUN project
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
29
05
2018
revised:
05
09
2018
accepted:
25
09
2018
pubmed:
23
10
2018
medline:
26
9
2020
entrez:
23
10
2018
Statut:
ppublish
Résumé
Breast cancer (BC) is the most commonly diagnosed cancer, and diet is suspected to play a role in its development. Dietary factors may mediate this process through modulation of inflammation, though findings from previous studies have not been consistent. We aimed to longitudinally assess the association between the dietary inflammatory index (DII We included 10,713 middle-aged, Spanish female university graduates from the SUN cohort. DII After 10.3 years of median follow-up, we identified 100 confirmed and 168 probable incident BC cases. The multivariable-adjusted HR for participants in the 4th quartile to the 1st quartile was 1.44 (95% CI 0.76-2.72; p-trend: 0.339) when confirmed cases were analyzed, and 1.20 (95% CI 0.72-1.99; p-trend: 0.757) for the probable cases. We neither observed statistically significant differences in regard to menopausal status. The apparent increase in risk between DII
Sections du résumé
BACKGROUND & AIMS
Breast cancer (BC) is the most commonly diagnosed cancer, and diet is suspected to play a role in its development. Dietary factors may mediate this process through modulation of inflammation, though findings from previous studies have not been consistent. We aimed to longitudinally assess the association between the dietary inflammatory index (DII
METHODS
We included 10,713 middle-aged, Spanish female university graduates from the SUN cohort. DII
RESULTS
After 10.3 years of median follow-up, we identified 100 confirmed and 168 probable incident BC cases. The multivariable-adjusted HR for participants in the 4th quartile to the 1st quartile was 1.44 (95% CI 0.76-2.72; p-trend: 0.339) when confirmed cases were analyzed, and 1.20 (95% CI 0.72-1.99; p-trend: 0.757) for the probable cases. We neither observed statistically significant differences in regard to menopausal status.
CONCLUSIONS
The apparent increase in risk between DII
Identifiants
pubmed: 30344023
pii: S0261-5614(18)32468-3
doi: 10.1016/j.clnu.2018.09.030
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2259-2268Subventions
Organisme : NIDDK NIH HHS
ID : R44 DK103377
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.