Further studies of the efficacy of military, commercial and novel skin decontaminants against the chemical warfare agents sulphur Mustard, Soman and VX.
Chemical warfare agent
Decontamination
Methyl salicylate
Percutaneous absorption
Skin
Soman
Sulphur mustard
VX
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
02
05
2018
revised:
25
09
2018
accepted:
19
10
2018
pubmed:
23
10
2018
medline:
15
1
2019
entrez:
23
10
2018
Statut:
ppublish
Résumé
Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a "therapeutic" window in which to mitigate skin absorption. Five potential candidates (itaconic acid, N,N'-methylenebisacrylamide, 2-trifluoromethylacrylic acid, fuller's earth and Fast-Act®) previously found effective against a simulant (methyl salicylate) were evaluated against a 10 μL droplet of All the decontaminants applied to the skin 5 min post exposure achieved a marked reduction in the amount of All of the products evaluated in this study performed well in reducing the dermal absorption of all the chemical warfare agents tested.
Sections du résumé
BACKGROUND/AIMS
OBJECTIVE
Following an incident involving toxic chemicals, deployment of countermeasures before the arrival of specialised services at the scene may provide a "therapeutic" window in which to mitigate skin absorption.
METHODS
METHODS
Five potential candidates (itaconic acid, N,N'-methylenebisacrylamide, 2-trifluoromethylacrylic acid, fuller's earth and Fast-Act®) previously found effective against a simulant (methyl salicylate) were evaluated against a 10 μL droplet of
RESULTS
RESULTS
All the decontaminants applied to the skin 5 min post exposure achieved a marked reduction in the amount of
CONCLUSION
CONCLUSIONS
All of the products evaluated in this study performed well in reducing the dermal absorption of all the chemical warfare agents tested.
Identifiants
pubmed: 30347232
pii: S0887-2333(18)30644-1
doi: 10.1016/j.tiv.2018.10.008
pii:
doi:
Substances chimiques
Chemical Warfare Agents
0
Organothiophosphorus Compounds
0
Soman
96-64-0
VX
9A4381183B
Mustard Gas
T8KEC9FH9P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
263-268Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.