In vitro and in silico studies of antioxidant activity of 2-thiazolylhydrazone derivatives.

Antineoplastic Agents / chemistry Antioxidants / chemistry Cell Line, Tumor Humans Hydrazones / chemistry Molecular Structure Oxidation-Reduction Structure-Activity Relationship Thiazoles / chemistry
2-Thiazolylhydrazone Antioxidant activity Chemometric Cytotoxic activity

Journal

Journal of molecular graphics & modelling
ISSN: 1873-4243
Titre abrégé: J Mol Graph Model
Pays: United States
ID NLM: 9716237

Informations de publication

Date de publication:
01 2019
Historique:
received: 08 06 2018
revised: 17 09 2018
accepted: 08 10 2018
pubmed: 23 10 2018
medline: 20 2 2020
entrez: 23 10 2018
Statut: ppublish

Résumé

The antioxidant potential of a series of thiazolylhydrazone derivatives was investigated using three different methods namely DPPH, ABTS and FRAP assays. In general, the tested compounds showed higher or comparable activity to that of curcumin, used as positive control. Chemometric analyses demonstrated that the presence of hydrazone moiety is required for the activity of this class of compounds. From these results, compound 4 was identified as the most promising molecule and was then selected for further studies. The antiproliferative effect of compound 4 was evaluated, being active in three (T47D, MDA-MB-231 and SKMEL) of the six cancer cell lines tested, with IC

Identifiants

DOI: 10.1016/j.jmgm.2018.10.007 PMID: 30347318
pubmed: 30347318
pii: S1093-3263(18)30451-0
doi: 10.1016/j.jmgm.2018.10.007
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Antioxidants 0
Hydrazones 0
Thiazoles 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106-112

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Vinícius Gonçalves Maltarollo (VG)

Department of Pharmaceutical Products, Pharmacy Faculty, Federal University of Minas Gerais, 6627 Antônio Carlos AVE, 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Marina Ferrara de Resende (MF)

Department of Foods, Pharmacy Faculty, Federal University of Minas Gerais, 6627 Antônio Carlos AVE, 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Thales Kronenberger (T)

Department of Internal Medicine VIII, University Hospital Tübingen, Otfried-Müller- Strasse 14, Tübingen, DE, 72076, Germany.

Cleudiomar Inácio Lino (CI)

Department of Pharmaceutical Products, Pharmacy Faculty, Federal University of Minas Gerais, 6627 Antônio Carlos AVE, 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Maria Clara Pinheiro Duarte Sampaio (MCPD)

Departament of Biochemistry, Laboratory of Immunomodulation and New Therapeutical Aproaches, Federal University of Pernambuco, Prof. Moraes Rêgo AVE, 50670-901, Recife, Pernambuco, Brazil.

Maira Galdino da Rocha Pitta (MGDR)

Departament of Biochemistry, Laboratory of Immunomodulation and New Therapeutical Aproaches, Federal University of Pernambuco, Prof. Moraes Rêgo AVE, 50670-901, Recife, Pernambuco, Brazil.

Moacyr Jesus Barreto de Melo Rêgo (MJBM)

Departament of Biochemistry, Laboratory of Immunomodulation and New Therapeutical Aproaches, Federal University of Pernambuco, Prof. Moraes Rêgo AVE, 50670-901, Recife, Pernambuco, Brazil.

Renata Adriana Labanca (RA)

Department of Foods, Pharmacy Faculty, Federal University of Minas Gerais, 6627 Antônio Carlos AVE, 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Renata Barbosa de Oliveira (RB)

Department of Pharmaceutical Products, Pharmacy Faculty, Federal University of Minas Gerais, 6627 Antônio Carlos AVE, 31270-901, Belo Horizonte, Minas Gerais, Brazil. Electronic address: renatabo@farmacia.ufmg.br.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › Hydrazones › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › In vitro and in silico studies of antioxidant...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › In vitro and in silico studies of antioxidant...