Photodynamic detection of a canine glioblastoma using 5-aminolevulinic acid.
Journal
The Journal of small animal practice
ISSN: 1748-5827
Titre abrégé: J Small Anim Pract
Pays: England
ID NLM: 0165053
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
13
12
2017
revised:
15
04
2018
accepted:
11
05
2018
pubmed:
24
10
2018
medline:
20
9
2020
entrez:
24
10
2018
Statut:
ppublish
Résumé
Photodynamic detection using 5-aminolevulinic acid has been used to identify the surgical margins during resection of human primary brain tumours. Although there are some reports on its use in malignant tumours in veterinary medicine, it has never been used for primary brain tumours. Here we describe a canine glioblastoma that was detected at autopsy with protoporphyrin IX fluorescence induced by orally administered 5-aminolevulinic acid. The fluorescence was strongest towards the centre of the lesion and was absent in normal brain tissue. Moreover, the fluorescence findings were consistent with MRI and histopathological findings. Our findings suggest that photodynamic detection using 5-aminolevulinic acid might be useful for intraoperative fluorescence-guided resection of malignant gliomas in dogs.
Substances chimiques
Aminolevulinic Acid
88755TAZ87
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
516-519Subventions
Organisme : SBI Pharmaceuticals Co., Ltd
Pays : International
Informations de copyright
© 2018 British Small Animal Veterinary Association.
Références
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