Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands.
antibody neutralization
antigenic drift
blockade antibody
immunocompromised
norovirus
receptor binding
viral evolution
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
10
10
2018
accepted:
12
10
2018
pubmed:
26
10
2018
medline:
23
10
2019
entrez:
26
10
2018
Statut:
epublish
Résumé
Emergent strains of human norovirus seed pandemic waves of disease. These new strains have altered ligand binding and antigenicity characteristics. Study of viral variants isolated from immunosuppressed patients with long-term norovirus infection indicates that initial virus
Identifiants
pubmed: 30355694
pii: JVI.01813-18
doi: 10.1128/JVI.01813-18
pmc: PMC6321922
pii:
doi:
Substances chimiques
Antibodies, Blocking
0
Antibodies, Viral
0
Capsid Proteins
0
Epitopes
0
Ligands
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203268/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R56 AI106006
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109761
Pays : United States
Informations de copyright
Copyright © 2019 Lindesmith et al.
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