Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops).
African green monkey
aging
diabetes
graded glucose infusion
insulinopenic
intravenous glucose tolerance test
nonhuman primates
oral glucose tolerance test
plasma insulin
vervet
Journal
Journal of medical primatology
ISSN: 1600-0684
Titre abrégé: J Med Primatol
Pays: Denmark
ID NLM: 0320626
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
09
03
2018
accepted:
27
07
2018
pubmed:
26
10
2018
medline:
16
4
2020
entrez:
26
10
2018
Statut:
ppublish
Résumé
Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys. Twenty-eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing (IVGTT), oral glucose tolerance testing (OGTT), and/or graded glucose infusion testing. Geriatric monkeys exhibited glucose intolerance with impaired glucose-stimulated insulin secretion following IVGTT. Repeat IVGTT and OGTT assessments were inconsistent. Monkeys with low glucose-stimulated insulin secretion after graded glucose infusion exhibited elevated blood glucose levels. IVGTT and graded glucose infusion protocols revealed differences in glucose tolerance among green monkeys at single time points, including age-dependent differences suggestive of shifts in pancreatic beta-cell functional capacity, but care should be applied to study design and the interpretation of data in the setting of longitudinal studies.
Sections du résumé
BACKGROUND
Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys.
METHODS
Twenty-eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing (IVGTT), oral glucose tolerance testing (OGTT), and/or graded glucose infusion testing.
RESULTS
Geriatric monkeys exhibited glucose intolerance with impaired glucose-stimulated insulin secretion following IVGTT. Repeat IVGTT and OGTT assessments were inconsistent. Monkeys with low glucose-stimulated insulin secretion after graded glucose infusion exhibited elevated blood glucose levels.
CONCLUSION
IVGTT and graded glucose infusion protocols revealed differences in glucose tolerance among green monkeys at single time points, including age-dependent differences suggestive of shifts in pancreatic beta-cell functional capacity, but care should be applied to study design and the interpretation of data in the setting of longitudinal studies.
Identifiants
pubmed: 30357856
doi: 10.1111/jmp.12374
pmc: PMC6587791
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-21Subventions
Organisme : RxGen Inc.
Pays : International
Organisme : Regeneron Pharmaceuticals Inc.
Pays : International
Informations de copyright
© 2018 The Authors. Journal of Medical Primatology published by John Wiley & Sons Ltd.
Références
J Med Primatol. 2013 Jun;42(3):165-8
pubmed: 23802316
J Med Primatol. 2019 Feb;48(1):10-21
pubmed: 30357856
J Formos Med Assoc. 1996 Aug;95(8):639-41
pubmed: 8870437
Lab Anim Sci. 1982 Jun;32(3):263-6
pubmed: 7098427
Lab Anim Sci. 1976 Oct;26(5):771-6
pubmed: 824499
Int J Endocrinol. 2012;2012:320482
pubmed: 22675349
Am J Vet Res. 1996 Sep;57(9):1294-8
pubmed: 8874721
J Clin Endocrinol Metab. 1985 Jan;60(1):13-20
pubmed: 3880560
Diabetes. 2003 Feb;52(2):380-6
pubmed: 12540611
Eur J Clin Pharmacol. 1977;11(1):15-8
pubmed: 832653
Diabet Med. 1998 Jul;15(7):539-53
pubmed: 9686693
Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R140-52
pubmed: 12388450
Diabetologia. 1990 Oct;33(10):631-4
pubmed: 2258002
J Clin Invest. 1973 Aug;52(8):2016-28
pubmed: 4719675
Aging (Albany NY). 2011 Jun;3(6):565-75
pubmed: 21765202
Diabetologia. 1988 Feb;31(2):123-5
pubmed: 3282953
Diabetes Care. 2012 Jan;35 Suppl 1:S64-71
pubmed: 22187472
Diabetes. 1983 Feb;32(2):175-80
pubmed: 6337897
Diabetes Care. 1995 Aug;18(8):1168-73
pubmed: 7587853
J Med Primatol. 2014 Jun;43(3):162-8
pubmed: 24697511
N Engl J Med. 2017 Apr 13;376(15):1419-1429
pubmed: 28402773
J Diabetes Sci Technol. 2012 May 01;6(3):503-14
pubmed: 22768880
Expert Opin Ther Targets. 2005 Apr;9(2):267-81
pubmed: 15934915
Nutrients. 2014 Jun 02;6(6):2165-78
pubmed: 24892374
Diabetol Metab Syndr. 2013 Jul 25;5(1):40
pubmed: 23886319
Exp Biol Med (Maywood). 2005 Nov;230(10):777-84
pubmed: 16246906
Pediatr Diabetes. 2015 Mar;16(2):129-37
pubmed: 23944770
Endocrinology. 1983 Mar;112(3):1098-109
pubmed: 6337043
J Clin Invest. 2000 Aug;106(4):459-65
pubmed: 10953020
Am J Cardiol. 2011 Aug 2;108(3 Suppl):3B-24B
pubmed: 21802577
Am J Primatol. 2007 Sep;69(9):1053-63
pubmed: 17294427