Proposed model for the prediction of intrahepatic covalently closed circular DNA level in patients with chronic hepatitis B.
chronic hepatitis B
hepatitis B core-related antigen
hepatitis B surface antigen
intrahepatic covalently closed circular DNA
predictive model
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN: 1386-6346
Titre abrégé: Hepatol Res
Pays: Netherlands
ID NLM: 9711801
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
06
09
2018
revised:
04
10
2018
accepted:
19
10
2018
pubmed:
26
10
2018
medline:
26
10
2018
entrez:
26
10
2018
Statut:
ppublish
Résumé
We sought to create a prediction model for intrahepatic covalently closed circular DNA (IH-cccDNA) level in chronic hepatitis B (CHB) patients and to validate the model's predictive accuracy. Patients who did not receive previous nucleoside analogue (NA) therapy were assigned to the training cohort (n = 57), and those who received previous NA therapy were assigned to the validation cohort (n = 69). Factors linked to IH-cccDNA levels in the training cohort were analyzed and a formula to predict IH-cccDNA levels was constructed. Next, the reproducibility of that formula was assessed. In the multivariate analysis for the prediction of IH-cccDNA level in the training cohort, fasting blood sugar (FBS) (P = 0.0227), hepatitis B e antigen (HBeAg) (P = 0.0067) and log Our proposed model for the prediction of IH-cccDNA level could be helpful in CHB patients.
Types de publication
Journal Article
Langues
eng
Pagination
271-283Subventions
Organisme : Japan Agency for Medical Research and Development
ID : 00101
Organisme : Japan Agency for Medical Research and Development
ID : 5532
Informations de copyright
© 2018 The Japan Society of Hepatology.