SLAM family receptors in natural killer cells - Mediators of adhesion, activation and inhibition via cis and trans interactions.
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
29
08
2018
revised:
18
10
2018
accepted:
19
10
2018
pubmed:
26
10
2018
medline:
31
3
2020
entrez:
26
10
2018
Statut:
ppublish
Résumé
SLAM family receptors are important for the fine-tuning of immune reactions. Their expression is restricted to cells of hematopoietic origin and most SLAM family receptors are their own ligand. Here we review how these receptors are involved in regulating the functions of Natural Killer (NK) cells. We discuss that promoting cellular adhesion may be a main function of SLAM family receptors in NK cells. The homophilic interactions of SLAM family receptors can not only occur in trans between different cells, but also in cis on the surface of the same cell. This cis interaction additionally modulates the function of the receptors and subsequently affects the activities of NK cells. Finally, SLAM-family receptors can also mediate inhibitory signals under certain conditions. These inhibitory signals can contribute to the functional maturation of NK cells during NK cell education. Therefore, SLAM family receptors are critically involved in many aspects of NK cell functionality.
Identifiants
pubmed: 30359773
pii: S1521-6616(18)30531-X
doi: 10.1016/j.clim.2018.10.011
pii:
doi:
Substances chimiques
Signaling Lymphocytic Activation Molecule Family
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-42Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.