Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease.
Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Autoimmune Diseases
/ diagnosis
Child
Child, Preschool
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1
/ complications
Diabetes Mellitus, Type 2
/ complications
Ethnicity
Female
Follow-Up Studies
Humans
Incidence
Infant
Logistic Models
Male
Middle Aged
Prevalence
Risk Factors
Young Adult
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
26
05
2018
accepted:
02
10
2018
pubmed:
27
10
2018
medline:
3
5
2019
entrez:
27
10
2018
Statut:
ppublish
Résumé
Type 1 diabetes (T1DM) is associated with other autoimmune diseases (AIDs), which may have serious health consequences. The epidemiology of AIDs in T1DM is not well defined in adults with T1DM. In this cross-sectional cohort study, we sought to characterize the incident ages and prevalence of AIDs in adults with T1DM across a wide age spectrum. A total of 1,212 adults seen at the Washington University Diabetes Center from 2011 to 2018 provided informed consent for the collection of their age, sex, race, and disease onset data. We performed paired association analyses based on age at onset of T1DM. Multivariate logistic regression was used to evaluate the independent effects of sex, race, T1DM age of onset, and T1DM duration on the prevalence of an additional AID. Mean ± SD age of T1DM onset was 21.2 ± 14.4 years. AID incidence and prevalence increased with age. Female sex strongly predicted AID risk. The most prevalent T1DM-associated AIDs were thyroid disease, collagen vascular diseases, and pernicious anemia. T1DM age of onset and T1DM duration predicted AID risk. Patients with late-onset T1DM after 30 years of age had higher risks of developing additional AIDs compared with patients with younger T1DM onset. The prevalence of AIDs in patients with T1DM increases with age and female sex. Later onset of T1DM is an independent and significant risk factor for developing additional AIDs. Individuals who are diagnosed with T1DM at older ages, particularly women, should be monitored for other autoimmune conditions.
Identifiants
pubmed: 30361208
pii: dc18-1157
doi: 10.2337/dc18-1157
pmc: PMC6300704
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-38Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007120
Pays : United States
Informations de copyright
© 2018 by the American Diabetes Association.
Références
Diabet Med. 2017 Jan;34(1):56-63
pubmed: 26996105
Diabetes Metab J. 2015 Apr;39(2):132-6
pubmed: 25922807
BMC Med. 2013 Apr 04;11:94
pubmed: 23556986
Am J Epidemiol. 1993 Dec 1;138(11):984-7
pubmed: 8256783
J Clin Endocrinol Metab. 2008 Feb;93(2):363-71
pubmed: 18029461
Endocrinol Metab Clin North Am. 2010 Sep;39(3):481-97
pubmed: 20723815
Lancet. 2016 Jun 4;387(10035):2340-2348
pubmed: 27302273
J Autoimmun. 2009 Nov-Dec;33(3-4):197-207
pubmed: 19819109
Diabet Med. 1994 Aug-Sep;11(7):650-5
pubmed: 7955989
J Clin Endocrinol Metab. 2016 Dec;101(12):4931-4937
pubmed: 27676394
Clin Immunol Immunopathol. 1997 Sep;84(3):223-43
pubmed: 9281381
Autoimmun Rev. 2012 Aug;11(10):754-65
pubmed: 22387972
Cell Mol Life Sci. 2012 May;69(10):1615-23
pubmed: 22466672
PLoS One. 2016 Mar 23;11(3):e0152168
pubmed: 27007574
Diabetes Care. 2018 Feb;41(2):311-317
pubmed: 29025879
Epidemiology. 2013 Sep;24(5):773-4
pubmed: 23903880
BMC Public Health. 2015 Mar 17;15:255
pubmed: 25849566
Lancet Diabetes Endocrinol. 2018 Feb;6(2):122-129
pubmed: 29199115
Diabetologia. 2004 Mar;47(3):377-384
pubmed: 14762657
Eur J Endocrinol. 2018 Jan;178(1):113-120
pubmed: 29066573
Diabet Med. 2000 Oct;17(10):749-51
pubmed: 11110510
N Engl J Med. 2017 Apr 13;376(15):1419-1429
pubmed: 28402773
Clin Exp Immunol. 2018 Jun;192(3):251-258
pubmed: 29431870
Diabetes Care. 2011 May;34(5):1211-3
pubmed: 21430083
J Clin Endocrinol Metab. 2018 May 1;103(5):1977-1984
pubmed: 29409002
Diabetes Metab Res Rev. 2011 Jul;27(5):493-8
pubmed: 21744463
Diabetes Care. 2005 Apr;28(4):850-5
pubmed: 15793184
Diabetes Care. 2005 Nov;28(11):2613-9
pubmed: 16249528
Acta Diabetol. 2015 Aug;52(4):801-7
pubmed: 25585594
Arthritis Rheum. 2009 Mar;60(3):653-60
pubmed: 19248096
Mayo Clin Proc. 2005 Nov;80(11):1429-34
pubmed: 16295022
Diabetes Care. 2000 Sep;23(9):1326-32
pubmed: 10977027
J Diabetes Complications. 2016 Nov - Dec;30(8):1640-1642
pubmed: 27592246
Rheumatol Int. 2017 Sep;37(9):1551-1557
pubmed: 28455559
Can J Diabetes. 2015 Dec;39(6):513-9
pubmed: 26293006
Lancet. 2009 Jun 13;373(9680):2027-33
pubmed: 19481249