Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes.

Animals Cell Nucleus / drug effects Cells, Cultured Chromatin / genetics Constitutive Androstane Receptor ErbB Receptors / genetics Erlotinib Hydrochloride / pharmacology Female Hepatocytes / drug effects Humans Mice Mice, Inbred C57BL Phenobarbital / pharmacology Protein Isoforms / genetics Receptors, Cytoplasmic and Nuclear / genetics Transcriptional Activation / drug effects

Journal

Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623

Informations de publication

Date de publication:
01 2019
Historique:
received: 09 07 2018
accepted: 19 10 2018
pubmed: 27 10 2018
medline: 18 6 2019
entrez: 27 10 2018
Statut: ppublish

Résumé

The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation. Much progress has been made in understanding the mechanism of activation of human CAR by drugs and xenobiotics. However, many aspects of the activation pathway remain to be elucidated. In this report, we have used viral constructs to express human CAR, its splice variants, and mutant CAR forms in hepatocytes from

Identifiants

DOI: 10.1124/mol.118.113555 PMID: 30361333 PMC: PMC6277922
pubmed: 30361333
pii: mol.118.113555
doi: 10.1124/mol.118.113555
pmc: PMC6277922
doi:

Substances chimiques

Chromatin 0
Constitutive Androstane Receptor 0
Protein Isoforms 0
Receptors, Cytoplasmic and Nuclear 0
Erlotinib Hydrochloride DA87705X9K
ErbB Receptors EC 2.7.10.1
Phenobarbital YQE403BP4D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

97-105

Subventions

Organisme : Cancer Research UK
ID : C4639/A10822
Pays : United Kingdom

Informations de copyright

Copyright © 2018 The Author(s).

Références

Drug Metab Dispos. 2008 Jun;36(6):1046-55
pubmed: 18332078
Mol Pharmacol. 2004 Mar;65(3):496-502
pubmed: 14978227
Nucleic Acids Res. 2003 Jun 15;31(12):3194-207
pubmed: 12799447
Nature. 1998 Oct 8;395(6702):612-5
pubmed: 9783588
PLoS One. 2014 Dec 26;9(12):e115663
pubmed: 25542016
Annu Rev Genet. 1985;19:209-52
pubmed: 3909942
Protein Cell. 2014 Feb;5(2):113-23
pubmed: 24474196
Toxicol Sci. 2014 Jun;139(2):501-11
pubmed: 24690595
Sci Signal. 2013 May 07;6(274):ra31
pubmed: 23652203
J Clin Invest. 2008 Sep;118(9):3228-39
pubmed: 18677425
Arch Toxicol. 2015 Jul;89(7):1045-55
pubmed: 25975989
J Pharmacol Exp Ther. 2007 Jan;320(1):72-80
pubmed: 17041008
In Vitro. 1981 Oct;17(10):913-25
pubmed: 6273298
Drug Metab Dispos. 2014 Jun;42(6):1022-30
pubmed: 24671958
Toxicol Sci. 2011 Apr;120(2):381-91
pubmed: 21227907
Nat Rev Drug Discov. 2004 Nov;3(11):950-64
pubmed: 15520817
Mol Cell Biol. 1998 Oct;18(10):5652-8
pubmed: 9742082
J Biol Chem. 2007 Dec 14;282(50):36766-76
pubmed: 17962186
Biochem J. 1992 Jan 15;281 ( Pt 2):359-68
pubmed: 1736885
Cell. 2002 Feb 22;108(4):465-74
pubmed: 11909518
J Biol Chem. 2009 Dec 11;284(50):34785-92
pubmed: 19858220
Mol Biol Evol. 2004 Oct;21(10):1923-37
pubmed: 15229292
Sci Rep. 2015 May 20;5:10405
pubmed: 25993555
In Vitro. 1981 Oct;17(10):926-34
pubmed: 7309042
Chem Biol Interact. 2010 Dec 5;188(3):512-25
pubmed: 20869355
Biochem J. 1998 Mar 1;330 ( Pt 2):889-95
pubmed: 9480906
Mol Pharmacol. 2007 May;71(5):1217-21
pubmed: 17314319
J Biol Chem. 2005 Feb 11;280(6):4367-73
pubmed: 15572372
Mol Pharmacol. 2005 Nov;68(5):1239-53
pubmed: 16099843
J Bone Miner Res. 1998 Mar;13(3):325-49
pubmed: 9525333
Mol Pharmacol. 2009 May;75(5):1005-13
pubmed: 19211671
Drug Metab Dispos. 2014 Jan;42(1):172-81
pubmed: 24194512
Mol Cell Biol. 2017 May 2;37(10):
pubmed: 28265001
Mol Endocrinol. 1994 Aug;8(8):996-1005
pubmed: 7997240
Toxicol Sci. 2011 Oct;123(2):550-62
pubmed: 21778469
Am J Physiol Cell Physiol. 2007 Nov;293(5):C1427-36
pubmed: 17728396
J Biol Chem. 2003 Apr 11;278(15):13480-6
pubmed: 12566435
Drug Metab Dispos. 2008 Jul;36(7):1322-31
pubmed: 18420780
J Biol Chem. 2003 May 9;278(19):17277-83
pubmed: 12611900
Drug Metab Dispos. 2017 May;45(5):532-539
pubmed: 28356313

Auteurs

Michael McMahon (M)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Shaohong Ding (S)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Lourdes Acosta Jimenez (LA)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Remi Terranova (R)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Marie-Apolline Gerard (MA)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Antonio Vitobello (A)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Jonathan Moggs (J)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

Colin J Henderson (CJ)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.).

C Roland Wolf (CR)

School of Medicine, Jacqui Wood Cancer Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom (M.M., S.D., L.A.J., C.J.H., C.R.W.) and Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel, Switzerland (R.T., M.-A.G., A.V., J.M.) c.r.wolf@dundee.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Cellules › Cellules cultivées › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur constitutif des androstanes › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Chlorhydrate d'erlotinib › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Barbituriques › Phénobarbital › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Constitutive androstane receptor 1 is...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › Constitutive androstane receptor 1 is...