Blood Vessel Invasion in Endometrial Cancer Is One of the Mechanisms of Spread to the Cervix.
Blood vessel
CD31
Endometrial cancer
Lympho-vascular invasion
Podoplanin
Journal
Pathology oncology research : POR
ISSN: 1532-2807
Titre abrégé: Pathol Oncol Res
Pays: Switzerland
ID NLM: 9706087
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
06
07
2018
accepted:
10
10
2018
pubmed:
27
10
2018
medline:
31
3
2020
entrez:
27
10
2018
Statut:
ppublish
Résumé
To evaluate the association between type of invaded vessels (blood or lymphatic) and cervical involvement in endometrial cancer (EC). Pathological slides of 93 patients with EC who had vascular space invasion in hematoxylin-eosin staining underwent immunohistochemical assay with CD31 and podoplanin. CD31 and podoplanin were used to identify blood and lymphatic invaded vessels, respectively. Cervical stromal invasion (CSI) was determined in 21 (30%) patients. The rate of CD31-positivity was significantly higher in patients with CSI than without (76.2 and 34.7%, p = 0.001; respectively). Podoplanin-positivity was determined in 47.6 and 81.6% of patients with and without CSI, respectively (p = 0.005). Age, myometrial invasion and the combination of CD31-positivity with podoplanin-negativity were found as independent predictors for CSI. Blood vessel invasion is an important factor for CSI in EC. Blood vessel invasion rather than lymphatic vessel invasion is one of the predominant ways by which EC spreads to the cervix.
Identifiants
pubmed: 30361902
doi: 10.1007/s12253-018-0498-1
pii: 10.1007/s12253-018-0498-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1431-1436Références
Obstet Gynecol. 1982 Jan;59(1):85-92
pubmed: 7078854
J Clin Pathol. 2003 Oct;56(10):786-8
pubmed: 14514787
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Int J Gynecol Cancer. 2018 Jan;28(1):161-167
pubmed: 28930810
Gynecol Oncol. 1992 Jun;45(3):294-8
pubmed: 1612507
Int J Gynecol Cancer. 2012 Oct;22(8):1442-8
pubmed: 22964524
Histopathology. 2009 Jul;55(1):1-9
pubmed: 19016903
Int J Gynecol Cancer. 2002 Jan-Feb;12(1):42-8
pubmed: 11860535
BMC Clin Pathol. 2013 Nov 25;13(1):31
pubmed: 24274633
Int J Gynecol Cancer. 2010 Apr;20(3):363-7
pubmed: 20375798
Gynecol Oncol. 2009 Jun;113(3):316-23
pubmed: 19345400
Cancer. 1991 Sep 15;68(6):1335-9
pubmed: 1873785
Int J Clin Oncol. 2013 Feb;18(1):105-9
pubmed: 22095247
J Gastroenterol Hepatol. 2010 Sep;25(9):1556-61
pubmed: 20796155
Adv Anat Pathol. 2002 May;9(3):145-84
pubmed: 11981113
Am J Surg Pathol. 2003 Aug;27(8):1080-8
pubmed: 12883240
Br J Cancer. 2006 Jun 5;94(11):1643-9
pubmed: 16670715
Int J Cancer. 2001 Jan 20;95(1):29-33
pubmed: 11241307
Mod Pathol. 2010 Aug;23(8):1073-9
pubmed: 20473276
Clin Cancer Res. 2001 Jan;7(1):93-7
pubmed: 11205924
J Natl Cancer Inst. 2000 Nov 1;92(21):1717-30
pubmed: 11058615
Obstet Gynecol. 1983 Sep;62(3):363-6
pubmed: 6877693
Urologe A. 2015 Jan;54(1):70-5
pubmed: 25391439
Am J Surg Pathol. 2012 Dec;36(12):1865-73
pubmed: 23154772
Science. 2011 Mar 25;331(6024):1559-64
pubmed: 21436443
Cancer. 1998 Feb 15;82(4):689-96
pubmed: 9477101
Rom J Morphol Embryol. 2010;51(4):677-82
pubmed: 21103625
Gynecol Oncol. 1991 Jan;40(1):46-7
pubmed: 1989914