Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection.
Journal
Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
02
07
2018
accepted:
16
10
2018
pubmed:
27
10
2018
medline:
30
5
2020
entrez:
27
10
2018
Statut:
ppublish
Résumé
Chronic hepatitis B infection is one of the major etiological causes of liver failure, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. This condition cannot be completely cured by currently available drugs due to the persistent existence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), the bona fide transcription template for HBV RNAs, in infected hepatocytes. Because quantifying cccDNA per se requires an invasive procedure, serum biomarkers reflecting intrahepatic cccDNA activity are warranted. Recently, a growing body of research suggests that the circulating HBV RNA may serve as a serum biomarker for HBV infection, treatment, and prognosis. In order to delineate the molecular and clinical characteristics of serum HBV RNA, we systematically reviewed the available literature on serum HBV RNA dating back to the early 1990s. In this review, we summarize the reported serum HBV RNA quantification methods and discuss the potential HBV RNA species in patient serum. We also compare the reported correlations of serum HBV RNA with other serological markers, including HBV DNA, hepatitis B surface antigen, e antigen, and core-related antigen, as well as their correlations with intrahepatic cccDNA, to assess their potential in clinical applications. Future directions for serum HBV RNA research are also discussed.
Identifiants
pubmed: 30362148
doi: 10.1002/hep.30325
pmc: PMC6438723
mid: NIHMS994350
doi:
Substances chimiques
Biomarkers
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1816-1827Subventions
Organisme : NIAID NIH HHS
ID : R01 AI134818
Pays : United States
Organisme : National Natural Science Foundation of China
ID : 81600475
Pays : International
Organisme : Guangzhou Science and Technology Plan Project
ID : 201604020002
Pays : International
Organisme : Guangzhou Science and Technology Plan Project
ID : 201804020001
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI123271
Pays : United States
Organisme : National Science and Technology Major Project of China
ID : 2017ZX10202202
Pays : International
Organisme : NIAID NIH HHS
ID : T32 AI060519
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI094474
Pays : United States
Organisme : Guangdong Natural Science and Technology Grant
ID : 2016A030313550
Pays : International
Organisme : Guangzhou Science and Technology Plan Project
ID : 201803040013
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI110762
Pays : United States
Organisme : National Natural Science Foundation of China
ID : U1401226
Pays : International
Informations de copyright
© 2018 by the American Association for the Study of Liver Diseases.
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