MicroRNAs and breast cancer stem cells: Potential role in breast cancer therapy.
breast cancer
breast cancer stem cells (BCSC)
cancer stem cells (CSCs)
metastasis
microRNAs (miRNAs)
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
06
05
2018
accepted:
24
07
2018
pubmed:
27
10
2018
medline:
17
3
2020
entrez:
27
10
2018
Statut:
ppublish
Résumé
MicroRNAs (miRNAs) can control cancer and cancer stem cells (CSCs), and this topic has drawn immense attention recently. Stem cells are a tiny population of a bulk of tumor cells that have enormous potential in expansion and metastasis of the tumor. miRNA have a crucial role in the management of the function of stem cells. This role is to either promote or suppress the tumor. In this review, we investigated the function and different characteristics of CSCs and function of the miRNAs that are related to them. We also demonstrated the role and efficacy of these miRNAs in breast cancer and breast cancer stem cells (BCSC). Eventually, we revealed the metastasis, tumor formation, and their role in the apoptosis process. Also, the therapeutic potential of miRNA as an effective method for the treatment of BCSC was described. Extensive research is required to investigate the employment or suppression of these miRNAs for therapeutics approached in different cancers in the future.
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3294-3306Informations de copyright
© 2018 Wiley Periodicals, Inc.