The hidden side of Parkinson's disease: Studying pain, anxiety and depression in animal models.
Anxiety
Depression
Non-motor symptoms
Pain
Parkinson’s disease
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
05
07
2018
revised:
14
09
2018
accepted:
12
10
2018
pubmed:
27
10
2018
medline:
12
2
2019
entrez:
27
10
2018
Statut:
ppublish
Résumé
Parkinson's disease is a neurodegenerative disease leading to the loss of midbrain dopamine neurons. It is well known and characterized by motor symptoms that are secondary to the loss of dopamine innervation, but it is also accompanied by a range of various non-motor symptoms, including pain and psychiatric disorders such as anxiety and depression. These non-motor symptoms usually appear at early stages of the disease, sometimes even before the first motor symptoms, and have a dramatic impact on the quality of life of the patients. We review here the present state-of-the-art concerning pain, anxiety and depression-like parameters in animal models of Parkinson's disease.
Identifiants
pubmed: 30365972
pii: S0149-7634(18)30505-0
doi: 10.1016/j.neubiorev.2018.10.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-352Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.