2B4 and CD48: A powerful couple of the immune system.

Animals CD48 Antigen / immunology Humans Hypersensitivity / immunology Signaling Lymphocytic Activation Molecule Family / immunology
2B4 Allergic Effector Unit (AEU) Allergy CD48 Eosinophils Mast cells SLAM receptors

Journal

Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537

Informations de publication

Date de publication:
07 2019
Historique:
received: 20 09 2018
revised: 22 10 2018
accepted: 22 10 2018
pubmed: 27 10 2018
medline: 31 3 2020
entrez: 27 10 2018
Statut: ppublish

Résumé

The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.

Identifiants

DOI: 10.1016/j.clim.2018.10.014 PMID: 30366105
pubmed: 30366105
pii: S1521-6616(18)30579-5
doi: 10.1016/j.clim.2018.10.014
pii:
doi:

Substances chimiques

CD244 protein, human 0
CD48 Antigen 0
Signaling Lymphocytic Activation Molecule Family 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

64-68

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Hadas Pahima (H)

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Pier Giorgio Puzzovio (PG)

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Francesca Levi-Schaffer (F)

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: francescal@ekmd.huji.ac.il.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › 2B4 and CD48: A powerful couple of the immune system.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Famille des molécules de signalisation de l'activation des lymphocytes › Antigène CD48 › 2B4 and CD48: A powerful couple of the immune system.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 2B4 and CD48: A powerful couple of the immune system.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › 2B4 and CD48: A powerful couple of the immune system.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Famille des molécules de signalisation de l'activation des lymphocytes › 2B4 and CD48: A powerful couple of the immune system.