Novel dual responsive alginate-based magnetic nanogels for onco-theranostics.

MRI Magnetic-targeted Onco-theranostics Superparamagnetic iron oxides nanoparticles pH and reductive-triggered

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
15 Jan 2019
Historique:
received: 18 04 2018
revised: 29 09 2018
accepted: 29 09 2018
entrez: 28 10 2018
pubmed: 28 10 2018
medline: 28 10 2018
Statut: ppublish

Résumé

The aim of this work was to obtain a novel onco-theranostic system for early diagnosis and improved chemotherapeutic outcome. Hybrid nanogels with magnetic and dual responsive properties were fabricated by covalently attaching superparamagnetic iron oxide nanoparticles (SPIONs) with a disulfide-modified alginate derivative, while simultaneously encapsulating the anticancer drug doxorubicin. The resulting nanogels exhibited magnetic-targeted characteristics, high drug loading content, co-triggered release behavior, high toxicity to tumor cells, low side effects to normal cells, and magnetic resonance imaging (MRI) functions. These findings proved that the hybrid nanogels have great potential as novel tumor-targeting nano-theranostic agents for simultaneous MRI imaging and efficient anti-tumor treatment.

Identifiants

DOI: 10.1016/j.carbpol.2018.09.084 PMID: 30366540
pubmed: 30366540
pii: S0144-8617(18)31171-8
doi: 10.1016/j.carbpol.2018.09.084
pii:
doi:

Types de publication

Journal Article

Langues

eng

Pagination

32-41

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Na Peng (N)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China. Electronic address: pengna@wust.edu.cn.

Xiao Ding (X)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Ziyu Wang (Z)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Yang Cheng (Y)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Zhiwei Gong (Z)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Xiangjiao Xu (X)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Xiaofang Gao (X)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Qun Cai (Q)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Shiwen Huang (S)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Yi Liu (Y)

Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China; College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China. Electronic address: yiliuchem@whu.edu.cn.

Classifications MeSH