Identifying Recurrent Malignant Glioma after Treatment Using Amide Proton Transfer-Weighted MR Imaging: A Validation Study with Image-Guided Stereotactic Biopsy.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
26
04
2018
revised:
06
09
2018
accepted:
22
10
2018
pubmed:
28
10
2018
medline:
28
2
2020
entrez:
28
10
2018
Statut:
ppublish
Résumé
To quantify the accuracy of amide proton transfer-weighted (APTw) MRI for identifying active glioma after treatment via radiographically guided stereotactic tissue validation. Eighteen of 21 patients had recurrent tumor, and 3 had treatment effect on clinical pathology. In 12 patients, there were multiple histopathologic assignments confirmed within the same tumor. Of the 64 total specimens, 20 specimens were active glioma, 27 mixed active and quiescent glioma, and 17 quiescent/no identifiable tumor. APTw signal intensity and histopathologic assignment, cellularity, and proliferation index had significant positive correlations ( APTw imaging hyperintensity may be a marker of active malignant glioma. It is able to distinguish between regions of heterogeneous abnormality on anatomic brain MRI with high sensitivity and specificity.
Identifiants
pubmed: 30366937
pii: 1078-0432.CCR-18-1233
doi: 10.1158/1078-0432.CCR-18-1233
pmc: PMC6335169
mid: NIHMS1511006
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
552-561Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB009731
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070024
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB015032
Pays : United States
Organisme : NINDS NIH HHS
ID : UG3 NS106937
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA228188
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA166171
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA227783
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015909
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
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