Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma.
Aged
Animals
Cancer-Associated Fibroblasts
/ pathology
Carcinoma, Squamous Cell
/ pathology
Cell Line, Tumor
Cell Movement
Esophageal Neoplasms
/ pathology
Female
Humans
Lymphatic Metastasis
Male
Mice, Inbred BALB C
Mice, Nude
Middle Aged
Survival Analysis
Transplantation, Heterologous
Tumor Microenvironment
cancer-associated fibroblasts
fibroblast activation protein (FAP)
lymph node metastasis
orthotopic mouse model
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
29
03
2018
revised:
29
09
2018
accepted:
11
10
2018
pubmed:
28
10
2018
medline:
28
5
2019
entrez:
28
10
2018
Statut:
ppublish
Résumé
Lymph node metastasis is a pathognomonic feature of spreading tumors, and overcoming metastasis is a challenge in attaining more favorable clinical outcomes. Esophageal cancer is an aggressive tumor for which lymph node metastasis is a strong poor prognostic factor, and the tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in particular, has been implicated in esophageal cancer progression. CAFs play a central role in the TME and have been reported to provide suitable conditions for the progression of esophageal cancer, similar to their role in other malignancies. However, little is known concerning the relevance of CAFs to the lymph node metastasis of esophageal cancer. Here, we used clinical samples of esophageal cancer to reveal that CAFs promote lymph node metastasis and subsequently verified the intercellular relationships in vitro and in vivo using an orthotopic metastatic mouse model. In the analysis of clinical samples, FAP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
828-840Informations de copyright
© 2018 UICC.