Histone deacetylase inhibitor panobinostat potentiates the anti-cancer effects of mesenchymal stem cell-based sTRAIL gene therapy against malignant glioma.

Adipose Tissue / cytology Animals Antineoplastic Agents / pharmacology Apoptosis / drug effects Brain Neoplasms / drug therapy Cell Survival / drug effects Chemotherapy, Adjuvant Coculture Techniques Female Genetic Therapy / methods Glioma / drug therapy Histone Deacetylase Inhibitors / pharmacology Humans Male Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells / metabolism Mice, Inbred BALB C Mice, Nude Middle Aged Panobinostat / pharmacology Phenotype Signal Transduction TNF-Related Apoptosis-Inducing Ligand / genetics Tumor Burden / drug effects Tumor Cells, Cultured Tumor Necrosis Factor Decoy Receptors / metabolism Xenograft Model Antitumor Assays
Antitumor effect Apoptosis Malignant glioma Panobinostat hAT-MSC.sTRAIL

Journal

Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 25 01 2018
revised: 25 09 2018
accepted: 09 10 2018
pubmed: 28 10 2018
medline: 5 11 2019
entrez: 28 10 2018
Statut: ppublish

Résumé

Human adipose tissue-derived mesenchymal stem cells expressing the secreted form of the tumor necrosis factor-related apoptosis-inducing ligand (hAT-MSC.sTRAIL) have demonstrated therapeutic activity against various tumors in preclinical studies. However, the limited expression of TRAIL death receptors remains a challenge. We evaluated the therapeutic efficacy of panobinostat in enhancing the sensitivity of hAT-MSC.sTRAIL-mediated apoptosis in malignant glioma. Panobinostat effectively inhibited all malignant glioma cells (IC

Identifiants

DOI: 10.1016/j.canlet.2018.10.012 PMID: 30367915
pubmed: 30367915
pii: S0304-3835(18)30626-8
doi: 10.1016/j.canlet.2018.10.012
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Histone Deacetylase Inhibitors 0
TNF-Related Apoptosis-Inducing Ligand 0
TNFSF10 protein, human 0
Tumor Necrosis Factor Decoy Receptors 0
Panobinostat 9647FM7Y3Z

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

161-169

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Seung Ah Choi (SA)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Chanhee Lee (C)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Pil Ae Kwak (PA)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Chul-Kee Park (CK)

Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Kyu-Chang Wang (KC)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Ji Hoon Phi (JH)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Ji Yeoun Lee (JY)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Anatomy, Seoul National University Hospital, Seoul, Republic of Korea.

Sangjoon Chong (S)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Seung-Ki Kim (SK)

Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: nsthomas@snu.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Eucaryotes › Animaux › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement médicamenteux adjuvant › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de coculture › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches mésenchymateuses › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Panobinostat › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand TRAIL › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Techniques d'investigation › Charge tumorale › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteurs leurres aux facteurs de nécrose tumorale › Histone deacetylase inhibitor panobinostat...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Histone deacetylase inhibitor panobinostat...