Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease.
Acetoacetate
Alzheimer's disease
Cognition
Ketogenic formula
Medium chain triglyceride
β-Hydroxybutyrate
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
received:
30
08
2018
revised:
11
10
2018
accepted:
22
10
2018
pubmed:
28
10
2018
medline:
12
3
2019
entrez:
28
10
2018
Statut:
ppublish
Résumé
Clinical and animal studies suggested that a medium-chain triglyceride (MCT)-based ketogenic diet provides an alternative energy substrate to the brain and has neuroprotective effects, but the clinical evidence is still scarce. Here we examined the effect of an MCT-based ketogenic formula on cognitive function in patients with Alzheimer's disease (AD). The subjects were 20 Japanese patients with mild-to-moderate AD (11 males, nine females, mean age 73.4 ± 6.0 years) who, on separate days, underwent neurocognitive tests 120 min after consuming 50 g of a ketogenic formula (Ketonformula
Identifiants
pubmed: 30367958
pii: S0304-3940(18)30730-4
doi: 10.1016/j.neulet.2018.10.048
pii:
doi:
Substances chimiques
Ketone Bodies
0
Triglycerides
0
Types de publication
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-236Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.