Relevance of electroencephalogram assessment in amyloid and tau pathology in rat.
Alzheimer Disease
/ diagnosis
Amyloid beta-Peptides
/ administration & dosage
Animals
Brain
/ physiopathology
DNA Fingerprinting
Dependovirus
/ genetics
Disease Models, Animal
Electroencephalography
Humans
Hymecromone
Male
Maze Learning
/ physiology
Memory, Short-Term
/ physiology
Peptide Fragments
/ administration & dosage
Phosphorylation
Rats, Sprague-Dawley
Recombinant Proteins
/ administration & dosage
Sleep, REM
/ physiology
tau Proteins
/ administration & dosage
Beta amyloid
Electroencephalography
Phosphorylated tau
Rapid eye movement
Theta waves
Water maze
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
23
05
2018
revised:
19
09
2018
accepted:
19
10
2018
pubmed:
28
10
2018
medline:
4
4
2019
entrez:
28
10
2018
Statut:
ppublish
Résumé
In order to contribute to a better knowledge on the relationship between amyloid and tau pathology, and electroencephalography (EEG) disturbances, the aim of this study was to evaluate the effects of injection of beta amyloid Abeta(1-42) peptide, tau (a recombinant AAV (Adeno-Associated Virus) containing the human transgene tau with the P301 L mutation on rats and the combination of both, on the power of brain's rhythm (delta, theta, alpha, beta and gamma waves) during the different sleep/wake states of animals by EEG recording. Currently, no preclinical studies explore the effect of the tau pathology on EEG. The experimentations were performed 3 weeks and 3 months post injections. Beta amyloid deposits and hyperphosphorylated Tau are observed by immunohistofluorescence, only in the hippocampus. Furthermore, using a radial arm water maze, the main effect was observed on working memory which was significantly impaired in Abeta-Tau group only 3 months post injections. However, on EEG, as early as the 3
Identifiants
pubmed: 30367970
pii: S0166-4328(18)30728-9
doi: 10.1016/j.bbr.2018.10.026
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
MAPT protein, human
0
Peptide Fragments
0
Recombinant Proteins
0
amyloid beta-protein (1-42)
0
tau Proteins
0
Hymecromone
3T5NG4Q468
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-134Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.