Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood.
EDEN mother-child cohort
early breastmilk
food allergy
growth factors
immune factors
Journal
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
ISSN: 1399-3038
Titre abrégé: Pediatr Allergy Immunol
Pays: England
ID NLM: 9106718
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
04
05
2018
revised:
28
08
2018
accepted:
06
10
2018
pubmed:
29
10
2018
medline:
20
3
2019
entrez:
29
10
2018
Statut:
ppublish
Résumé
Breastmilk (BM) may participate in driving gut barrier function and immunity in the neonate. We analyzed immune and growth factor concentrations in early BM and their association with maternal/environmental characteristics and with food allergy (FA) in childhood. One BM sample was collected in maternity from some mothers in the EDEN birth cohort (n = 2002 mother-child dyads). A random selection was performed among available samples (subcohort, n = 272), for which all deliveries were full-term, various maternal/environmental characteristics were recorded, and parents answered yearly the question "Has a medical doctor diagnosed a FA in your child?" (26 parent-reported FA cases). Only samples collected between day 2 and day 6 post-partum were considered for descriptive analysis (n = 263). Samples for all other FA cases available were added to the subcohort (46 additional cases; "casecohort" design). Fifty cytokines, antibodies, and growth factor concentrations were determined using multiplexed kits and analyzed using robust statistical procedures. BM components exhibited wide concentration ranges and global day-to-day variation. Different clusters of correlated factors appeared, with components from the main cluster related to maternal diet during pregnancy. Primiparity was positively associated with eleven other components, whereas other factors (eg, maternal atopy and smoking) were related to fewer components. Finally, the casecohort design highlighted a positive association between CXCL10, TNFβ, and IL-2 concentrations and reported FA in childhood. Beyond the unique description of early BM composition, we show that immune information transmitted to the neonate is related to various maternal factors and identified components associated with FA diagnosis in childhood.
Sections du résumé
BACKGROUND
Breastmilk (BM) may participate in driving gut barrier function and immunity in the neonate. We analyzed immune and growth factor concentrations in early BM and their association with maternal/environmental characteristics and with food allergy (FA) in childhood.
METHODS
One BM sample was collected in maternity from some mothers in the EDEN birth cohort (n = 2002 mother-child dyads). A random selection was performed among available samples (subcohort, n = 272), for which all deliveries were full-term, various maternal/environmental characteristics were recorded, and parents answered yearly the question "Has a medical doctor diagnosed a FA in your child?" (26 parent-reported FA cases). Only samples collected between day 2 and day 6 post-partum were considered for descriptive analysis (n = 263). Samples for all other FA cases available were added to the subcohort (46 additional cases; "casecohort" design). Fifty cytokines, antibodies, and growth factor concentrations were determined using multiplexed kits and analyzed using robust statistical procedures.
RESULTS
BM components exhibited wide concentration ranges and global day-to-day variation. Different clusters of correlated factors appeared, with components from the main cluster related to maternal diet during pregnancy. Primiparity was positively associated with eleven other components, whereas other factors (eg, maternal atopy and smoking) were related to fewer components. Finally, the casecohort design highlighted a positive association between CXCL10, TNFβ, and IL-2 concentrations and reported FA in childhood.
CONCLUSION
Beyond the unique description of early BM composition, we show that immune information transmitted to the neonate is related to various maternal factors and identified components associated with FA diagnosis in childhood.
Substances chimiques
Cytokines
0
Immunoglobulins
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-116Subventions
Organisme : Fondation pour la Recherche Médicale (FRM)
Pays : International
Organisme : French Ministry of Research: Federative Research Institutes and Cohort Program
Pays : International
Organisme : INSERM Human Nutrition National Research Program
Pays : International
Organisme : Diabetes National Research Program
Pays : International
Organisme : French Ministry of Health
Pays : International
Organisme : French Agency for Environment Security (AFSSET)
Pays : International
Organisme : French National Institute for Population Health Surveillance (InVS)
Pays : International
Organisme : Paris-Sud University
Pays : International
Organisme : French National Institute for Health Education (INPES)
Pays : International
Organisme : Nestlé
Pays : International
Organisme : Mutuelle Générale de l'Education Nationale (MGEN)
Pays : International
Organisme : French-speaking association for the study of diabetes and metabolism (ALFEDIAM)
Pays : International
Organisme : National Agency for Research
Pays : International
Organisme : National Institute for Research in Public Health
Pays : International
Organisme : INRA (Institut National de la Recherche Agronomique)
Pays : International
Organisme : CEA (Commissariat à l'Énergie Atomique et aux Énergies Alternatives)
Pays : International
Organisme : French National Alliance for Life Sciences and Health (Aviesan)
Pays : International
Organisme : Multi-organization Thematic Institutes-Public Health
Pays : International
Informations de copyright
© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.