Hepcidin and iron regulatory proteins coordinately regulate ferroportin 1 expression in the brain of mice.
Animals
Brain
/ metabolism
Cation Transport Proteins
/ metabolism
Cell Membrane
/ metabolism
Cells, Cultured
Fibroblasts
/ metabolism
Hepcidins
/ metabolism
Homeostasis
/ physiology
Iron
/ metabolism
Iron-Regulatory Proteins
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
RNA, Messenger
/ metabolism
Up-Regulation
/ physiology
ferroportin 1 (FPN1)
hepcidin
iron metabolism
iron regulatory proteins (IRPs)
iron-responsive element (IRE)
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
21
07
2018
accepted:
10
09
2018
pubmed:
30
10
2018
medline:
31
3
2020
entrez:
30
10
2018
Statut:
ppublish
Résumé
Iron plays an essential role in various cellular metabolic processes of the body. Maintenance of cellular iron homeostasis is particularly important for keeping the normal functions of the cells. Ferroportin 1 (FPN1) is the currently only known iron exporter on the cell membrane. It has been indicated that the regulation of FPN1 in response to the alteration of iron level mainly involves two processes, posttranscriptional repression by iron regulatory proteins (IRPs) and posttranslational degradation by hepcidin, the major iron-sensing hormone. However, whether there is any communication between the two types of regulations or which one plays dominant role has not been reported. In our study with IRP2
Substances chimiques
Cation Transport Proteins
0
Hepcidins
0
Iron-Regulatory Proteins
0
RNA, Messenger
0
metal transporting protein 1
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7600-7607Informations de copyright
© 2018 Wiley Periodicals, Inc.