Cellular biology of fracture healing.
bone regeneration
bone repair
fracture healing
Journal
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ISSN: 1554-527X
Titre abrégé: J Orthop Res
Pays: United States
ID NLM: 8404726
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
29
05
2018
accepted:
27
08
2018
pubmed:
30
10
2018
medline:
5
11
2019
entrez:
30
10
2018
Statut:
ppublish
Résumé
The biology of bone healing is a rapidly developing science. Advances in transgenic and gene-targeted mice have enabled tissue and cell-specific investigations of skeletal regeneration. As an example, only recently has it been recognized that chondrocytes convert to osteoblasts during healing bone, and only several years prior, seminal publications reported definitively that the primary tissues contributing bone forming cells during regeneration were the periosteum and endosteum. While genetically modified animals offer incredible insights into the temporal and spatial importance of various gene products, the complexity and rapidity of healing-coupled with the heterogeneity of animal models-renders studies of regenerative biology challenging. Herein, cells that play a key role in bone healing will be reviewed and extracellular mediators regulating their behavior discussed. We will focus on recent studies that explore novel roles of inflammation in bone healing, and the origins and fates of various cells in the fracture environment. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
Identifiants
pubmed: 30370699
doi: 10.1002/jor.24170
pmc: PMC6542569
mid: NIHMS1024877
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-50Subventions
Organisme : NIAMS NIH HHS
ID : F30 AR071201
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR066028
Pays : United States
Informations de copyright
© 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Références
J Orthop Res. 2010 Mar;28(3):384-9
pubmed: 19780203
PLoS One. 2013 Dec 31;8(12):e84232
pubmed: 24391920
Dev Cell. 2012 Mar 13;22(3):597-609
pubmed: 22421045
Cells Tissues Organs. 2001;169(3):285-94
pubmed: 11455125
Tissue Eng Part B Rev. 2010 Aug;16(4):427-34
pubmed: 20196645
Clin Cases Miner Bone Metab. 2010 Jan;7(1):11-4
pubmed: 22461283
Nat Med. 2004 Aug;10(8):858-64
pubmed: 15235597
Life Sci. 1996;59(2):61-83
pubmed: 8699924
Clin Orthop Relat Res. 1977 Nov-Dec;(129):299-304
pubmed: 608290
PLoS Genet. 2011 Nov;7(11):e1002356
pubmed: 22072985
Clin Oral Implants Res. 2011 Jun;22(6):578-86
pubmed: 21054552
J Orthop Trauma. 2014;28 Suppl 1:S20-3
pubmed: 24378431
Cell. 2015 Jan 15;160(1-2):269-84
pubmed: 25594183
Cell. 1997 May 30;89(5):765-71
pubmed: 9182764
Cell. 1997 May 30;89(5):747-54
pubmed: 9182762
Proc Natl Acad Sci U S A. 1989 Mar;86(6):2018-20
pubmed: 2928316
J Bone Miner Res. 2010 Jul;25(7):1604-15
pubmed: 20200974
J Bone Miner Res. 2011 Jul;26(7):1447-56
pubmed: 21305609
J Orthop Res. 2005 Nov;23(6):1300-7
pubmed: 15936915
Mol Cell Biol. 2008 Aug;28(16):4999-5013
pubmed: 18559420
J Bone Joint Surg Br. 2000 May;82(4):601-13
pubmed: 10855892
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9656-61
pubmed: 12118119
PLoS One. 2012;7(7):e40737
pubmed: 22911707
Sci Rep. 2017 Feb 22;7:42385
pubmed: 28225019
Bone. 2004 Apr;34(4):680-8
pubmed: 15050899
Sci Transl Med. 2013 Mar 20;5(177):177ra36
pubmed: 23515078
J Orthop Surg Res. 2014 Jun 05;9:45
pubmed: 24902588
J Biol Chem. 2012 May 4;287(19):15728-38
pubmed: 22416138
Bone. 2012 Jul;51(1):168-80
pubmed: 22391215
J Orthop Res. 2012 Nov;30(11):1860-6
pubmed: 22528744
Iowa Orthop J. 2006;26:17-26
pubmed: 16789443
Cell Stem Cell. 2014 Aug 7;15(2):154-68
pubmed: 24953181
Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S41-55
pubmed: 9917625
J Surg Orthop Adv. 2005 Summer;14(2):64-72
pubmed: 16115430
J Cell Sci. 2000 Feb;113 ( Pt 3):377-81
pubmed: 10639325
Nat Genet. 1999 May;22(1):85-9
pubmed: 10319868
J Bone Miner Res. 2002 Mar;17(3):513-20
pubmed: 11874242
PLoS Genet. 2014 Dec 04;10(12):e1004820
pubmed: 25474590
J Clin Invest. 2018 Apr 2;128(4):1429-1441
pubmed: 29504949
J Bone Miner Res. 2009 Feb;24(2):251-64
pubmed: 18847332
Bonekey Rep. 2013 Jun 26;2:373
pubmed: 25035807
Bone. 2007 Sep;41(3):331-9
pubmed: 17613296
PLoS One. 2014 Aug 18;9(8):e104954
pubmed: 25133509
EMBO J. 2008 Feb 6;27(3):535-45
pubmed: 18219273
J Bone Miner Res. 2002 Jun;17(6):963-76
pubmed: 12054171
J Orthop Res. 2013 Jun;31(6):935-43
pubmed: 23280580
Bone. 2007 Dec;41(6):928-36
pubmed: 17921078
Injury. 2008 Oct;39(10):1119-26
pubmed: 18656866
Acta Physiol Hung. 2009 Mar;96(1):19-28
pubmed: 19264039
J Clin Invest. 2015 Sep;125(9):3723
pubmed: 26325037
Nat Commun. 2016 Mar 11;7:10928
pubmed: 26965320
Odontology. 2007 Jul;95(1):1-9
pubmed: 17660975
Bone. 1995 Apr;16(4):455-60
pubmed: 7605706
Am J Pathol. 2007 Feb;170(2):427-35
pubmed: 17255310
J Bone Miner Res. 2009 Feb;24(2):274-82
pubmed: 18847330
J Bone Miner Res. 1999 Nov;14(11):1805-15
pubmed: 10571679
J Orthop Res. 2008 Oct;26(10):1384-9
pubmed: 18464248
J Bone Miner Res. 2015 Jun;30(6):1090-102
pubmed: 25487241
Hum Mol Genet. 2001 Mar 1;10(5):537-43
pubmed: 11181578
J Bone Miner Res. 2014 Dec;29(12):2653-65
pubmed: 24862038
Nat Commun. 2015 May 19;6:7131
pubmed: 25988592
J Bone Joint Surg Am. 1995 Jun;77(6):940-56
pubmed: 7782368
Nat Med. 2009 Jul;15(7):757-65
pubmed: 19584867
J Trauma. 1999 Oct;47(4):752-9
pubmed: 10528613
J Bone Miner Res. 2009 Feb;24(2):196-208
pubmed: 19016594
J Orthop Trauma. 1995;9(5):392-400
pubmed: 8537842
BMC Syst Biol. 2011 May 23;5:82
pubmed: 21605425
Am J Pathol. 2001 Nov;159(5):1689-99
pubmed: 11696430
J Bone Miner Res. 2007 Apr;22(4):560-8
pubmed: 17243865
Nat Genet. 2006 Dec;38(12):1424-9
pubmed: 17099713
Eur J Clin Invest. 1979 Oct;9(5):333-9
pubmed: 118026
Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70
pubmed: 16203988
J Bone Miner Res. 2003 Sep;18(9):1584-92
pubmed: 12968667
Development. 2017 Jan 15;144(2):221-234
pubmed: 28096214
Bone. 2010 Mar;46(3):841-51
pubmed: 19913648
Curr Osteoporos Rep. 2009 Jul;7(2):64-9
pubmed: 19631031
J Clin Invest. 2007 Jun;117(6):1616-26
pubmed: 17549257
J Biomed Mater Res B Appl Biomater. 2003 Apr 15;65(1):150-6
pubmed: 12632384
Elife. 2014 Sep 25;3:e03696
pubmed: 25255216
J Orthop Res. 2013 Oct;31(10):1585-96
pubmed: 23775935
Dev Cell. 2005 May;8(5):739-50
pubmed: 15866164
Connect Tissue Res. 1996;35(1-4):85-91
pubmed: 9084646
Development. 2002 Apr;129(8):1893-904
pubmed: 11934855
J Orthop Res. 2011 Sep;29(9):1437-42
pubmed: 21445992
J Clin Invest. 2016 Apr 1;126(4):1471-81
pubmed: 26950423
Bone. 2013 Jan;52(1):220-9
pubmed: 23063782
J Orthop Res. 2018 Jan;36(1):149-158
pubmed: 28708309
Mech Dev. 2001 Feb;100(2):245-50
pubmed: 11165481
Exp Gerontol. 2002 Dec;37(12):1325-31
pubmed: 12559402
Nat Immunol. 2002 Apr;3(4):329-33
pubmed: 11919569
Dev Cell. 2005 May;8(5):751-64
pubmed: 15866165
J Orthop Res. 2010 Jun;28(6):778-84
pubmed: 20041490
Mol Cell Biol. 1997 Apr;17(4):2336-46
pubmed: 9121483
Nat Genet. 1997 Jun;16(2):174-8
pubmed: 9171829
Biochem Biophys Res Commun. 2013 Nov 29;441(4):886-90
pubmed: 24211207
Tissue Eng Part A. 2015 Feb;21(3-4):594-602
pubmed: 25251779
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19004-9
pubmed: 17142326
Am J Pathol. 2009 Oct;175(4):1574-85
pubmed: 19745063
Blood Cells Mol Dis. 2007 Sep-Oct;39(2):212-20
pubmed: 17553709
PLoS One. 2016 Feb 05;11(2):e0147465
pubmed: 26849055
J Cell Biochem. 1996 Jul;62(1):1-9
pubmed: 8836870
Orthopedics. 2011 Jun;34(6):450
pubmed: 21661676
Bone. 2008 May;42(5):932-41
pubmed: 18326482
J Bone Joint Surg Br. 2000 Jul;82(5):655-8
pubmed: 10963160
Immunity. 2010 May 28;32(5):593-604
pubmed: 20510870
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
PLoS One. 2014 Jun 09;9(6):e99656
pubmed: 24911161
IUBMB Life. 2005 Jun;57(6):389-95
pubmed: 16012047
PLoS One. 2012;7(6):e40044
pubmed: 22768215
Development. 2011 Apr;138(8):1507-19
pubmed: 21367821
Acta Orthop Scand. 1980 Aug;51(4):595-600
pubmed: 7446048
J Bone Miner Res. 2014;29(5):1283-94
pubmed: 24190076
J Bone Miner Res. 2011 Jan;26(1):113-24
pubmed: 20641004
J Orthop Res. 2010 Jul;28(7):928-36
pubmed: 20063381
Dev Cell. 2010 Aug 17;19(2):329-44
pubmed: 20708594
PLoS One. 2013 Nov 18;8(11):e81341
pubmed: 24260573
Nat Rev Rheumatol. 2012 Jan 31;8(3):133-43
pubmed: 22293759
Clin Orthop Relat Res. 1975 Jan-Feb;(106):357-65
pubmed: 1126089
J Clin Invest. 2006 May;116(5):1230-42
pubmed: 16614757
J Bone Joint Surg Am. 2008 Feb;90 Suppl 1:14-8
pubmed: 18292351
Tissue Eng Part B Rev. 2008 Jun;14(2):179-86
pubmed: 18544015
Bone. 2010 Jul;47(1):65-73
pubmed: 20348041
J Bone Miner Res. 2008 May;23(5):596-609
pubmed: 18433297
Nature. 2013 Mar 21;495(7441):375-8
pubmed: 23485973
J Bone Miner Res. 1996 Jun;11(6):737-45
pubmed: 8725170
PLoS One. 2007 Nov 07;2(11):e1150
pubmed: 17987127
Dev Biol. 2004 Oct 1;274(1):188-200
pubmed: 15355797
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12097-102
pubmed: 25092332
Cell. 2002 Jan 11;108(1):17-29
pubmed: 11792318
Calcif Tissue Int. 2005 Apr;76(4):280-6
pubmed: 15812581
J Clin Invest. 2000 Dec;106(12):1481-8
pubmed: 11120755
Cold Spring Harb Perspect Biol. 2011 Oct 01;3(10):a009712
pubmed: 21875984
Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S132-47
pubmed: 9917634
Arthritis Rheum. 2009 Mar;60(3):813-23
pubmed: 19248097
Stem Cells. 2009 Aug;27(8):1887-98
pubmed: 19544445
Bone Miner. 1992 Oct;19(1):1-20
pubmed: 1422302
J Orthop Res. 2010 Aug;28(8):1000-6
pubmed: 20108320
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20764-9
pubmed: 19075223
J Cell Biochem. 2016 Mar;117(3):599-611
pubmed: 26252425
PLoS Med. 2007 Jul 31;4(7):e249
pubmed: 17676991
Bone. 2015 Feb;71:63-75
pubmed: 25263522
J Bone Miner Res. 2002 Feb;17(2):221-30
pubmed: 11811552
Bone. 2013 Jan;52(1):111-9
pubmed: 23010105
J Bone Miner Res. 2014;29(5):1269-82
pubmed: 24259230
J Bone Miner Res. 2015 Jan;30(1):95-105
pubmed: 25130304
J Orthop Res. 2001 Jan;19(1):78-84
pubmed: 11332624
Sci Rep. 2017 Oct 25;7(1):14061
pubmed: 29070810
Dev Biol. 1997 Mar 1;183(1):108-21
pubmed: 9119111
J Histochem Cytochem. 2012 Jul;60(7):537-49
pubmed: 22562557
Immunobiology. 2005;210(2-4):121-6
pubmed: 16164018
J Bone Miner Res. 2009 Jun;24(6):1043-54
pubmed: 19123916
J Orthop Res. 2002 Sep;20(5):1091-8
pubmed: 12382977
J Leukoc Biol. 2010 Jan;87(1):59-67
pubmed: 20052800
J Bone Miner Res. 2012 Aug;27(8):1695-707
pubmed: 22467241
Arthritis Res Ther. 2003;5(1):5-7
pubmed: 12716441
Injury. 2009 Dec;40 Suppl 3:S4-7
pubmed: 20082790
J Orthop Res. 2017 Nov;35(11):2378-2385
pubmed: 28248001
J Anat. 1950 Jul;84(3):236-61
pubmed: 15436329
J Cell Physiol. 2008 Apr;215(1):234-42
pubmed: 18205179
J Orthop Res. 2007 Jan;25(1):51-61
pubmed: 17019699
Cell. 1997 May 30;89(5):755-64
pubmed: 9182763
Contemp Orthop. 1995 Jun;30(6):489-93
pubmed: 10150380
J Orthop Res. 2003 Jul;21(4):670-5
pubmed: 12798067
Apoptosis. 2004 May;9(3):265-77
pubmed: 15258458
Blood. 1987 Mar;69(3):899-907
pubmed: 3493045
Mol Cell Biol. 2008 Oct;28(20):6402-12
pubmed: 18710934
J Bone Miner Res. 2014 Jul;29(7):1522-30
pubmed: 24470120
Injury. 2006 Sep;37(9):827-37
pubmed: 16497308
Bone. 2014 Oct;67:208-21
pubmed: 25016962
Dis Model Mech. 2010 Jul-Aug;3(7-8):451-8
pubmed: 20354109
Development. 2010 Mar;137(6):901-11
pubmed: 20179096
J Orthop Res. 2012 Apr;30(4):581-6
pubmed: 21922535
Acta Orthop Scand. 1992 Jun;63(3):330-3
pubmed: 1609602
Dev Biol. 2014 Oct 15;394(2):292-304
pubmed: 25131195
J Bone Miner Res. 2007 Feb;22(2):286-97
pubmed: 17087627
Development. 2003 Sep;130(17):4123-33
pubmed: 12874132
Dev Cell. 2005 May;8(5):727-38
pubmed: 15866163
FASEB J. 2004 Jun;18(9):980-2
pubmed: 15084518
J Biomech. 2010 Aug 26;43(12):2418-24
pubmed: 20546756
J Cereb Blood Flow Metab. 2014 Sep;34(9):1425-9
pubmed: 24984897
J Clin Invest. 2002 Jun;109(11):1405-15
pubmed: 12045254
Bone. 2014 Sep;66:72-81
pubmed: 24928497
J Bone Miner Res. 2011 Jul;26(7):1517-32
pubmed: 21305607
PLoS One. 2013 Jul 03;8(7):e68726
pubmed: 23844237
Nat Med. 1999 Jun;5(6):623-8
pubmed: 10371499
Blood. 2005 Feb 1;105(3):1068-77
pubmed: 15388583
Bone. 2006 Jul;39(1):5-16
pubmed: 16459154
Genes Dev. 1999 Sep 15;13(18):2412-24
pubmed: 10500098
J Bone Miner Res. 2007 Mar;22(3):366-74
pubmed: 17181398
Bone. 2014 Sep;66:277-86
pubmed: 24973690
J Exp Med. 2005 Aug 1;202(3):345-51
pubmed: 16061724
Am J Pathol. 2014 Dec;184(12):3192-204
pubmed: 25285719
Osteoporos Int. 2011 Jun;22(6):1955-65
pubmed: 20838768
Stem Cells. 2012 Feb;30(2):187-96
pubmed: 22083974