Strategies for the Design of Donors and Precursors of Reactive Sulfur Species.
donors
hydrogen sulfide
persulfides
polysulfides
reactive sulfur species
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
15 Mar 2019
15 Mar 2019
Historique:
received:
26
09
2018
revised:
27
10
2018
pubmed:
30
10
2018
medline:
30
10
2018
entrez:
30
10
2018
Statut:
ppublish
Résumé
Reactive sulfur species (RSS) play regulatory roles in biological systems. Many RSS are highly reactive and transient molecules, making their study difficult. RSS donors or precursors, which are used to specifically produce or deliver RSS, are useful research tools, as well as possible therapeutic agents. In this Minireview, we summarized the chemical strategies that have been used in the design of donors/precursors of hydrogen sulfide relevant RSS (including hydrogen sulfide, hydrogen polysulfides, persulfides, and S-nitroso-hydrogen sulfide). The potential problems of applying these strategies in biological settings are also discussed.
Identifiants
pubmed: 30372550
doi: 10.1002/chem.201804895
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4005-4016Subventions
Organisme : National Institutes of Health
ID : R01GM125968
Organisme : National Institutes of Health
ID : R01HL116571
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.