A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study.

Aged Aging / psychology Alzheimer Disease / prevention & control Cognitive Dysfunction / prevention & control Exercise / psychology Female Humans Life Style Male Middle Aged Patient Compliance
Adherence cerebrovascular disease mild cognitive impairment physical activity subjective memory complaints

Journal

Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863

Informations de publication

Date de publication:
2019
Historique:
pubmed: 30 10 2018
medline: 21 10 2020
entrez: 30 10 2018
Statut: ppublish

Résumé

Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer's disease. To examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer's disease. Participants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL) were randomized to a PA or control group (n = 106). The control group continued with their usual lifestyle. The PA group received a 24-month home-based program with a target of 150 minutes/week of moderate PA and a behavioral intervention. Retention (participants remaining) and PA adherence (PA group only, percent PA completed to the PA prescribed) were determined at 6, 12, 18, and 24 months. Assessments at baseline, 6, 12, and 24 months included, PA; fitness; body composition and fat distribution. Key outcome measures were PA adherence and PA. The 24-month retention rate (97.2%) and the median PA adherence 91.67% (Q1-Q3, 81.96, 100.00) were excellent. In the long-term the intervention group achieved significantly better improvements in PA levels, leg strength, fat mass and fat distribution compared to the control. This study demonstrates that in this target group, long-term PA adherence is achievable and has physical health benefits.

Sections du résumé

BACKGROUND
Previous studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer's disease.
OBJECTIVE
To examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer's disease.
METHODS
Participants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL) were randomized to a PA or control group (n = 106). The control group continued with their usual lifestyle. The PA group received a 24-month home-based program with a target of 150 minutes/week of moderate PA and a behavioral intervention. Retention (participants remaining) and PA adherence (PA group only, percent PA completed to the PA prescribed) were determined at 6, 12, 18, and 24 months. Assessments at baseline, 6, 12, and 24 months included, PA; fitness; body composition and fat distribution. Key outcome measures were PA adherence and PA.
RESULTS
The 24-month retention rate (97.2%) and the median PA adherence 91.67% (Q1-Q3, 81.96, 100.00) were excellent. In the long-term the intervention group achieved significantly better improvements in PA levels, leg strength, fat mass and fat distribution compared to the control.
CONCLUSION
This study demonstrates that in this target group, long-term PA adherence is achievable and has physical health benefits.

Identifiants

DOI: 10.3233/JAD-180521 PMID: 30372680 PMC: PMC6700652
pubmed: 30372680
pii: JAD180521
doi: 10.3233/JAD-180521
pmc: PMC6700652
doi:

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

S187-S205

Références

Am J Health Promot. 1992 Jul-Aug;6(6):424-9
pubmed: 10146803
Int J Geriatr Psychiatry. 1999 Oct;14(10):858-65
pubmed: 10521885
Med Sci Sports Exerc. 2001 Jul;33(7):1126-41
pubmed: 11445760
Am J Prev Med. 2002 Feb;22(2):120-33
pubmed: 11818183
Am J Epidemiol. 2002 Jul 15;156(2):132-8
pubmed: 12117704
Am J Clin Nutr. 2002 Aug;76(2):473-81
pubmed: 12145025
Prev Med. 2003 Jan;36(1):17-29
pubmed: 12473421
Arch Intern Med. 2003 Jul 14;163(13):1524-8
pubmed: 12860573
Sports Med. 2004;34(1):1-8
pubmed: 14715035
Health Educ Behav. 2004 Apr;31(2):143-64
pubmed: 15090118
J Gerontol A Biol Sci Med Sci. 2004 Nov;59(11):1207-12
pubmed: 15602077
BMJ. 2005 Jun 11;330(7504):1360
pubmed: 15863436
Arch Neurol. 2005 Oct;62(10):1556-60
pubmed: 16216938
J Am Geriatr Soc. 2006 May;54(5):743-9
pubmed: 16696738
Neurology. 2008 Sep 30;71(14):1057-64
pubmed: 18367704
JAMA. 2008 Sep 3;300(9):1027-37
pubmed: 18768414
J Gerontol A Biol Sci Med Sci. 2009 May;64(5):575-80
pubmed: 19276190
Int Psychogeriatr. 2009 Aug;21(4):672-87
pubmed: 19470201
Am J Psychiatry. 1991 Jan;148(1):102-5
pubmed: 1984692
J Am Geriatr Soc. 1991 Feb;39(2):142-8
pubmed: 1991946
J Aging Phys Act. 2009 Oct;17(4):398-415
pubmed: 19940321
Australas J Ageing. 2010 Jun;29(2):81-7
pubmed: 20553539
J Am Med Dir Assoc. 2011 May;12(4):249-56
pubmed: 21527165
Neurology. 2011 May 3;76(18):1568-74
pubmed: 21536637
Br J Nutr. 2012 Apr;107(7):1085-91
pubmed: 21810289
J Alzheimers Dis. 2012;28(3):647-54
pubmed: 22045479
BMC Psychiatry. 2012 Oct 11;12:167
pubmed: 23050829
BMC Neurol. 2012 Oct 31;12:128
pubmed: 23113898
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):445-55
pubmed: 23189083
Prev Med. 2013 Dec;57(6):824-30
pubmed: 24076011
Br J Sports Med. 2014 Feb;48(3):239-43
pubmed: 24276781
Am J Occup Ther. 2014 Jan-Feb;68(1):50-6
pubmed: 24367955
Obes Facts. 2014;7(1):26-35
pubmed: 24457527
NeuroRehabilitation. 2014 Jan 1;35(2):271-8
pubmed: 24990029
Lancet Neurol. 2014 Aug;13(8):788-94
pubmed: 25030513
J Aging Phys Act. 2015 Oct;23(4):659-68
pubmed: 25414947
J Frailty Aging. 2016;5(2):82-7
pubmed: 27224498
J Am Med Dir Assoc. 2016 Dec 1;17(12):1164.e7-1164.e15
pubmed: 27816484
Geriatr Gerontol Int. 2016 Nov;16(11):1235-1236
pubmed: 27870509
Prev Med Rep. 2017 May 18;7:38-45
pubmed: 28593121
J Phys Act Health. 2006 Jul;3(3):257-266
pubmed: 28834503
BMC Geriatr. 2017 Sep 13;17(1):215
pubmed: 28903738
J Physiother. 2018 Jan;64(1):4-15
pubmed: 29289581
Front Med (Lausanne). 2017 Dec 18;4:230
pubmed: 29326936
J Am Geriatr Soc. 2018 Mar;66(3):487-495
pubmed: 29363108
BMJ. 2018 May 16;361:k1675
pubmed: 29769247
Med Sci Sports Exerc. 1982;14(5):377-81
pubmed: 7154893
Rev Med Univ Navarra. 1997 Jan-Mar;41(1):6-11
pubmed: 9527716

Auteurs

Kay L Cox (KL)

Medical School University of Western Australia, Perth, Australia.

Elizabeth V Cyarto (EV)

Bolton Clarke Research Institute, Melbourne, Australia.
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.

Kathryn A Ellis (KA)

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.

David Ames (D)

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.

Patricia Desmond (P)

Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Australia.

Pramit Phal (P)

Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Australia.
Epworth Medical Imaging, Richmond, Victoria, Australia.

Matthew J Sharman (MJ)

School of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.

Cassandra Szoeke (C)

Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia.
School of Psychology, Australian Catholic University, Melbourne, Australia.

Christopher C Rowe (CC)

Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia.
Melbourne Dementia Research Centre, University of Melbourne, Melbourne, Australia.

Colin L Masters (CL)

The Florey Institute, The University of Melbourne, Australia.

Emily You (E)

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.

Sally Burrows (S)

Medical School University of Western Australia, Perth, Australia.

Michelle M Y Lai (MMY)

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.

Nicola T Lautenschlager (NT)

Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
WA Centre for Health & Ageing, University of Western Australia, Perth, Australia.
NorthWestern Mental Health, Melbourne Health, Melbourne, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Activités humaines › Exercice physique › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A Randomized Controlled Trial of Adherence to...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Prestations des soins de santé › Attitude envers la santé › Adhésion et observance thérapeutiques › Acceptation des soins par les patients › Observance par le patient › A Randomized Controlled Trial of Adherence to...