Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.

Cytokines Humans Interleukin-12 Neoplasms State Medicine Tumor Microenvironment

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
01 01 2019
Historique:
received: 18 09 2018
revised: 10 10 2018
accepted: 25 10 2018
pubmed: 1 11 2018
medline: 9 10 2019
entrez: 1 11 2018
Statut: ppublish

Résumé

Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.

Identifiants

DOI: 10.1158/1078-0432.CCR-18-2819 PMID: 30377197
pubmed: 30377197
pii: 1078-0432.CCR-18-2819
doi: 10.1158/1078-0432.CCR-18-2819
doi:

Substances chimiques

Cytokines 0
Interleukin-12 187348-17-0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-11

Commentaires et corrections

Type : CommentOn

Informations de copyright

©2018 American Association for Cancer Research.

Auteurs

H Kim Lyerly (HK)

Department of Surgery, Duke University, Durham, North Carolina. lyerl001@mc.duke.edu.
Department of Pathology, Duke University, Durham, North Carolina.
Department of Immunology, Duke University, Durham, North Carolina.
ORCID: 0000-0002-0063-4770

Takuya Osada (T)

Department of Surgery, Duke University, Durham, North Carolina.

Zachary C Hartman (ZC)

Department of Surgery, Duke University, Durham, North Carolina.
Department of Pathology, Duke University, Durham, North Carolina.
ORCID: 0000-0001-6549-8207

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Right Time and Place for IL12: Targeted...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Right Time and Place for IL12: Targeted...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-12 › Right Time and Place for IL12: Targeted...
questionsmedicales.fr › Tumeurs › Right Time and Place for IL12: Targeted...
questionsmedicales.fr › Organisations et économie des soins de santé › Médecine d'État › Right Time and Place for IL12: Targeted...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Right Time and Place for IL12: Targeted...