Risk prediction of severe reaction to oral challenge test of cow's milk.
Anaphylaxis
Food allergy
Multivariate logistic regression
Oral food challenge
Prediction model
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
04
06
2018
accepted:
19
10
2018
revised:
14
10
2018
pubmed:
1
11
2018
medline:
29
1
2019
entrez:
1
11
2018
Statut:
ppublish
Résumé
Cow's milk is one of the most common food allergens among children. Oral food challenge tests determine the threshold dose of allergens, but have not been standardized. To reduce the severe reactions, we developed a practical model of the test. We studied 111 high-risk patients who underwent a first milk oral food challenge on the risk-stratified dose between 2011 and 2017 for predicting the severe reaction risk. Severe reactions were defined as showing > 3 of Sampson's classification grade. Twenty-eight patients (25%) showed severe reactions without death. Prior to oral food challenge, severe reaction patients experienced milk avoidance (71% vs. 45%, p = 0.02) or bronchial asthma (61% vs. 28%, p = 0.003) more frequently and showed higher milk-specific IgE levels (median 28.3 vs. 7.7 U
Identifiants
pubmed: 30377799
doi: 10.1007/s00431-018-3274-z
pii: 10.1007/s00431-018-3274-z
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-188Références
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