Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation.
default mode network
magnetic resonance imaging
salience network
stimulation
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
24
07
2018
revised:
04
09
2018
accepted:
03
10
2018
pubmed:
1
11
2018
medline:
28
5
2020
entrez:
1
11
2018
Statut:
ppublish
Résumé
Despite its widespread use in cognitive studies, there is still limited understanding of whether and how transcranial direct current stimulation (tDCS) modulates brain network function. To clarify its physiological effects, we assessed brain network function using functional magnetic resonance imaging (fMRI) simultaneously acquired during tDCS stimulation. Cognitive state was manipulated by having subjects perform a Choice Reaction Task or being at "rest." A novel factorial design was used to assess the effects of brain state and polarity. Anodal and cathodal tDCS were applied to the right inferior frontal gyrus (rIFG), a region involved in controlling activity large-scale intrinsic connectivity networks during switches of cognitive state. tDCS produced widespread modulation of brain activity in a polarity and brain state dependent manner. In the absence of task, the main effect of tDCS was to accentuate default mode network (DMN) activation and salience network (SN) deactivation. In contrast, during task performance, tDCS increased SN activation. In the absence of task, the main effect of anodal tDCS was more pronounced, whereas cathodal tDCS had a greater effect during task performance. Cathodal tDCS also accentuated the within-DMN connectivity associated with task performance. There were minimal main effects of stimulation on network connectivity. These results demonstrate that rIFG tDCS can modulate the activity and functional connectivity of large-scale brain networks involved in cognitive function, in a brain state and polarity dependent manner. This study provides an important insight into mechanisms by which tDCS may modulate cognitive function, and also has implications for the design of future stimulation studies.
Identifiants
pubmed: 30378206
doi: 10.1002/hbm.24420
pmc: PMC6387619
mid: EMS81785
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-915Subventions
Organisme : NIMH NIH HHS
ID : R21 MH110217
Pays : United States
Organisme : Wellcome Trust
ID : 103045/Z/13/Z103429/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust Clinical Research Training Fellowship
Pays : International
Organisme : Programme Grants for Applied Research
ID : NIHR-RP-011-048
Pays : International
Organisme : National Institute for Health Research (NIHR) Professorship
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health
ID : NIHR-RP-011-048
Pays : United Kingdom
Organisme : NIH Clinical Center
ID : MH110217MH111439
Pays : International
Organisme : NIMH NIH HHS
ID : R01 MH111439
Pays : United States
Organisme : NIHR Imperial College London Biomedical Research Centre
Pays : International
Organisme : Sir Henry Wellcome Trust Fellowship
ID : 103045/Z/13/Z
Pays : International
Organisme : NIHR Imperial BRC
ID : NIHR-RP-011-048
Pays : International
Organisme : Wellcome Trust
ID : 103045
Pays : United Kingdom
Organisme : NIH HHS
ID : 103429/Z/13/Z
Pays : United States
Organisme : Wellcome Trust
ID : 103429
Pays : United Kingdom
Informations de copyright
© 2018 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
Références
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Brain. 2011 Aug;134(Pt 8):2233-47
pubmed: 21841202
Hum Brain Mapp. 2017 Jan;38(1):41-52
pubmed: 27489137
Front Hum Neurosci. 2013 Dec 12;7:857
pubmed: 24376413
Hum Brain Mapp. 2019 Feb 15;40(3):904-915
pubmed: 30378206
Brain Cogn. 2014 Nov;91:87-94
pubmed: 25265321
Brain Stimul. 2015 May-Jun;8(3):535-50
pubmed: 25701175
Brain Stimul. 2012 Jul;5(3):252-263
pubmed: 21962981
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:4575-8
pubmed: 23366946
Brain Stimul. 2015 Mar-Apr;8(2):253-9
pubmed: 25465291
Brain Res. 2015 Jan 12;1594:92-107
pubmed: 25312829
J Physiol. 2013 May 15;591(10):2563-78
pubmed: 23478132
Hum Brain Mapp. 2013 Apr;34(4):923-35
pubmed: 22109746
Nat Commun. 2016 Mar 22;7:11100
pubmed: 27000523
Front Neurol. 2017 Feb 09;8:29
pubmed: 28232816
Exp Brain Res. 2012 Jan;216(1):1-10
pubmed: 21989847
Brain Stimul. 2012 Oct;5(4):547-53
pubmed: 22019081
Neuroimage. 2011 Mar 15;55(2):590-6
pubmed: 21211569
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12569-74
pubmed: 18723676
Ann Neurol. 1990 Nov;28(5):597-613
pubmed: 2260847
Neuroimage. 2015 Apr 1;109:140-50
pubmed: 25613437
Brain Stimul. 2014 May-Jun;7(3):468-75
pubmed: 24630848
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16616-21
pubmed: 24062451
Trends Cogn Sci. 2010 Jun;14(6):277-90
pubmed: 20493761
Neuroimage. 2012 Jul 16;61(4):1277-86
pubmed: 22484411
Soc Cogn Affect Neurosci. 2012 Jun;7(5):604-9
pubmed: 22569188
Brain Connect. 2017 Apr;7(3):182-196
pubmed: 28142257
Front Cell Neurosci. 2015 May 12;9:181
pubmed: 26029052
Neuroimage. 2016 Oct 15;140:134-40
pubmed: 26748077
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
Eur J Neurosci. 2015 Dec;42(11):2904-14
pubmed: 26414683
Alzheimers Dement. 2015 Sep;11(9):1032-40
pubmed: 25449530
Front Hum Neurosci. 2016 Feb 04;10:30
pubmed: 26869909
Neuroimage. 1997 Oct;6(3):218-29
pubmed: 9344826
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):676-82
pubmed: 11209064
Brain. 2013 Jun;136(Pt 6):1929-41
pubmed: 23576128
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
pubmed: 15976020
Neuroimage. 2014 Mar;88:155-61
pubmed: 24287440
J Neurophysiol. 1965 Jan;28:166-85
pubmed: 14244793
Neuroscientist. 2011 Feb;17(1):37-53
pubmed: 21343407
J Physiol. 2005 Oct 1;568(Pt 1):291-303
pubmed: 16002441
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13
pubmed: 16087444
PLoS One. 2012;7(1):e30971
pubmed: 22303478
PLoS One. 2014 Dec 05;9(12):e114244
pubmed: 25478912
J Physiol. 2000 Sep 15;527 Pt 3:633-9
pubmed: 10990547
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Trends Neurosci. 2000 Oct;23(10):475-83
pubmed: 11006464
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Neuroimage. 2014 Oct 1;99:237-43
pubmed: 24904994
Neuroimage. 2015 Nov 15;122:96-104
pubmed: 26220743
Dialogues Clin Neurosci. 2013 Sep;15(3):247-62
pubmed: 24174898
Restor Neurol Neurosci. 2017;35(6):631-642
pubmed: 29172010
J Neurosci. 2014 Aug 13;34(33):10798-807
pubmed: 25122883
Front Hum Neurosci. 2013 May 07;7:183
pubmed: 23675337
Nature. 2001 Jul 12;412(6843):150-7
pubmed: 11449264
Elife. 2017 Mar 14;6:
pubmed: 28288700
Brain Stimul. 2009 Oct;2(4):215-28, 228.e1-3
pubmed: 20161507
Hum Brain Mapp. 2012 Oct;33(10):2499-508
pubmed: 21922602
Spat Vis. 1997;10(4):433-6
pubmed: 9176952
Neuroimage. 2009 May 15;46(1):64-72
pubmed: 19233295
Psychiatry Clin Neurosci. 2012 Mar;66(2):138-45
pubmed: 22353326
Neuropsychologia. 2012 Feb;50(3):396-402
pubmed: 22223077
Ann N Y Acad Sci. 2008 Mar;1124:1-38
pubmed: 18400922
Neuroimage. 2014 Jul 15;95:232-47
pubmed: 24657355
Neuroimage. 2008 Aug 15;42(2):717-25
pubmed: 18572418
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
J Neurosci. 2006 Dec 20;26(51):13338-43
pubmed: 17182784
Neuroimage. 2016 Oct 15;140:118-25
pubmed: 26458516
Neurosci Lett. 2013 Feb 28;539:7-10
pubmed: 23416318
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:222-5
pubmed: 26736240
Eur J Neurosci. 2007 Nov;26(9):2687-91
pubmed: 17970738
Brain Stimul. 2017 Jan - Feb;10(1):36-45
pubmed: 27717601
Front Hum Neurosci. 2013 Apr 30;7:161
pubmed: 23641206
J Neurosci. 2009 Apr 22;29(16):5202-6
pubmed: 19386916
BMC Neurosci. 2010 Mar 16;11:38
pubmed: 20233439
Trends Cogn Sci. 2015 Aug;19(8):445-52
pubmed: 26160027
Neuroimage. 2014 Jan 15;85 Pt 3:895-908
pubmed: 23933040
J Neurosci. 2014 Jun 4;34(23):7886-98
pubmed: 24899711
Behav Brain Res. 2009 Aug 12;201(2):239-43
pubmed: 19428640