Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes.
Animals
Disease Models, Animal
Drug Resistance, Viral
HIV Infections
/ drug therapy
HIV Integrase Inhibitors
/ administration & dosage
Heterocyclic Compounds, 3-Ring
/ administration & dosage
Humans
Macaca mulatta
Mutation
Oxazines
Piperazines
Pyridones
RNA, Viral
/ blood
Simian Acquired Immunodeficiency Syndrome
/ drug therapy
Simian Immunodeficiency Virus
/ drug effects
Treatment Outcome
HIV
SIV
animal models
dolutegravir
resistance
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
06
07
2018
accepted:
24
10
2018
pubmed:
2
11
2018
medline:
23
10
2019
entrez:
2
11
2018
Statut:
epublish
Résumé
Drug resistance remains a major concern for human immunodeficiency virus (HIV) treatment. To date, very few resistance mutations have emerged in first-line combination therapy that includes the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG).
Identifiants
pubmed: 30381490
pii: JVI.01189-18
doi: 10.1128/JVI.01189-18
pmc: PMC6321921
pii:
doi:
Substances chimiques
HIV Integrase Inhibitors
0
Heterocyclic Compounds, 3-Ring
0
Oxazines
0
Piperazines
0
Pyridones
0
RNA, Viral
0
dolutegravir
DKO1W9H7M1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CCR NIH HHS
ID : HHSN261200800001C
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States
Organisme : NIH HHS
ID : P51 OD011107
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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