Computing the ankle-brachial index with parallel computational fluid dynamics.
Ankle-brachial index
Computational fluid dynamics
Hemodynamics
Journal
Journal of biomechanics
ISSN: 1873-2380
Titre abrégé: J Biomech
Pays: United States
ID NLM: 0157375
Informations de publication
Date de publication:
03 01 2019
03 01 2019
Historique:
received:
16
01
2018
revised:
09
10
2018
accepted:
10
10
2018
pubmed:
6
11
2018
medline:
14
6
2019
entrez:
3
11
2018
Statut:
ppublish
Résumé
The ankle-brachial index (ABI), a ratio of arterial blood pressure in the ankles and upper arms, is used to diagnose and monitor circulatory conditions such as coarctation of the aorta and peripheral artery disease. Computational simulations of the ABI can potentially determine the parameters that produce an ABI indicative of ischemia or other abnormalities in blood flow. However, 0- and 1-D computational methods are limited in describing a 3-D patient-derived geometry. Thus, we present a massively parallel framework for computational fluid dynamics (CFD) simulations in the full arterial system. Using the lattice Boltzmann method to solve the Navier-Stokes equations, we employ highly parallelized and scalable methods to generate the simulation domain and efficiently distribute the computational load among processors. For the first time, we compute an ABI with 3-D CFD. In this proof-of-concept study, we investigate the dependence of ABI on the presence of stenoses, or narrowed regions of the arteries, by directly modifying the arterial geometry. As a result, our framework enables the computation a hemodynamic factor characterizing flow at the scale of the full arterial system, in a manner that is extensible to patient-specific imaging data and holds potential for treatment planning.
Identifiants
pubmed: 30385003
pii: S0021-9290(18)30772-3
doi: 10.1016/j.jbiomech.2018.10.007
pmc: PMC6666426
mid: NIHMS1511228
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-37Subventions
Organisme : NIH HHS
ID : DP5 OD019876
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 May;61(5A):5307-20
pubmed: 11031578
Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Apr;65(4 Pt 2B):046308
pubmed: 12006014
J Am Coll Cardiol. 2004 Aug 4;44(3):618-23
pubmed: 15358030
Eur Heart J. 2004 Oct;25(20):1853-9
pubmed: 15474701
IEEE Trans Vis Comput Graph. 2005 May-Jun;11(3):243-53
pubmed: 15868824
J Biomech. 2006;39(5):873-84
pubmed: 16488226
Tex Heart Inst J. 2006;33(4):463-8
pubmed: 17215971
J Biomech. 2007;40(13):3023-8
pubmed: 17445820
J Am Coll Cardiol. 2007 Jun 26;49(25):2379-93
pubmed: 17599600
Atherosclerosis. 2008 Mar;197(1):1-11
pubmed: 18076886
J Thorac Cardiovasc Surg. 2008 Jan;135(1):62-8
pubmed: 18179920
Circ J. 2008 Apr;72(4):605-10
pubmed: 18362433
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 May;77(5 Pt 2):056703
pubmed: 18643191
Circulation. 2008 Dec 2;118(23):e714-833
pubmed: 18997169
Med Biol Eng Comput. 2009 Jul;47(7):743-55
pubmed: 19198911
Vasc Med. 2010 Oct;15(5):361-9
pubmed: 20926495
Med Phys. 2010 Sep;37(9):4902-15
pubmed: 20964209
J Biomech Eng. 2011 Sep;133(9):091008
pubmed: 22010743
Rev Port Cardiol. 2012 May;31(5):381-4
pubmed: 22480937
Circulation. 2012 Dec 11;126(24):2890-909
pubmed: 23159553
Med Phys. 2013 Apr;40(4):043701
pubmed: 23556927
J Am Coll Cardiol. 2013 Jun 4;61(22):2233-41
pubmed: 23562923
J Comput Phys. 2013 Jul 1;244:22-40
pubmed: 23729840
ScientificWorldJournal. 2013 Sep 05;2013:185691
pubmed: 24089601
J Med Device. 2013 Dec;7(4):0409231-409231
pubmed: 24895523
Circ Cardiovasc Imaging. 2014 Nov;7(6):905-11
pubmed: 25190591
Circulation. 2015 May 26;131(21):1884-931
pubmed: 25896865
J Biomech. 2015 Jul 16;48(10):1922-9
pubmed: 25911249
Cardiovasc Eng Technol. 2011 Mar;2(1):2-14
pubmed: 26316899
J Biomech Eng. 2016 Feb;138(2):021011
pubmed: 26593324
J Biomech. 2016 Jul 26;49(11):2143-2151
pubmed: 26718062
Cardiovasc Eng Technol. 2016 Jun;7(2):148-58
pubmed: 26983961
Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:3429-3432
pubmed: 28269039
J Biomech. 2017 Jul 26;60:15-21
pubmed: 28673664
J Comput Sci. 2015 Jul;9:70-75
pubmed: 29152011
J Cardiol Cases. 2011 Sep 06;4(3):e172-e175
pubmed: 30546712
Br Heart J. 1995 Mar;73(3):270-6
pubmed: 7727189
J Biomech. 1998 May;31(5):453-62
pubmed: 9727343