Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs.


Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 2019
Historique:
received: 12 09 2018
revised: 24 10 2018
accepted: 27 10 2018
pubmed: 6 11 2018
medline: 5 3 2019
entrez: 3 11 2018
Statut: ppublish

Résumé

In recent years, rigid analogs of phenylalkylamine hallucinogens have appeared as recreational drugs. Examples include 2-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b']difuran-4-yl)ethan-1-amine (2C-B-FLY) and 1-(8-bromobenzo[1,2-b;4,5-b']difuran-4-yl)-2-aminopropane (Bromo-DragonFLY, DOB-DFLY). Although some rigid compounds such as DOB-DFLY reportedly have higher potency than their non-rigid counterparts, it is not clear whether the same is true for 2C-B-FLY and other tetrahydrobenzodifurans. In the present study, the head twitch response (HTR), a 5-HT

Identifiants

pubmed: 30385253
pii: S0028-3908(18)30614-2
doi: 10.1016/j.neuropharm.2018.10.037
pmc: PMC6863604
mid: NIHMS1513002
pii:
doi:

Substances chimiques

Hallucinogens 0
DOM 2,5-Dimethoxy-4-Methylamphetamine 15588-95-1
2,5-dimethoxy-4-bromoamphetamine 32156-26-6

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

368-376

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA041336
Pays : United States

Informations de copyright

Published by Elsevier Ltd.

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Auteurs

Adam L Halberstadt (AL)

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA; Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA, 92161, USA. Electronic address: ahalberstadt@ucsd.edu.

Muhammad Chatha (M)

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0804, USA.

Alexander Stratford (A)

Synex Synthetics BV, Karveelweg 20, 6222 NH, Maastricht, the Netherlands.

Matthias Grill (M)

Lipomed AG, Fabrikmattenweg 4, CH-4144, Arlesheim, Switzerland.

Simon D Brandt (SD)

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.

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Classifications MeSH