Iron oxide/bismuth oxide nanocomposites coated by graphene quantum dots: "Three-in-one" theranostic agents for simultaneous CT/MR imaging-guided in vitro photothermal therapy.
Fe/Bi
In vitro
MRI
Nanotheranostic
Photothermal therapy
X-ray CT
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
09
08
2018
revised:
25
10
2018
accepted:
26
10
2018
pubmed:
6
11
2018
medline:
4
9
2019
entrez:
3
11
2018
Statut:
ppublish
Résumé
The all-in-one nanoprobes (NPs) have drawn biomedical attention in the cancer therapy field due to simultaneously combing the capabilities of therapeutic and diagnostic methods into a single nanoprobe. In this study, we developed a theranostic probe based on superparamagnetic iron oxide (SPIO) and bismuth oxide (Bi The GQDs-Fe/Bi nanocomposites showed strong light absorbance profile with wide-band in the near-infrared region, without any sharp peak or decline. The highest photo-to-thermal conversion efficacy (η), was found to be 31.8% with the high photostability upon the irradiation of NIR 808-nm laser. The results of in vitro photothermal ablation of cancerous cells demonstrated that the cells significantly killed in the presence of NPs (∼53.4%) with a dose-dependent manner in comparison to only laser group (3.0%). In GQDs-Fe/Bi nanocomposites, Bi with a high atomic number (Z = 83) exhibited a superior X-ray attenuation capability (175%) than the clinical CT agent-used dotarem, also, SPIO with excellent magnetization property showed strong T Our results demonstrate that the developed NPs can incorporate dual-modality imaging capability into a photo absorber for CT/MR imaging-guided tumor PTT.
Sections du résumé
BACKGROUND
BACKGROUND
The all-in-one nanoprobes (NPs) have drawn biomedical attention in the cancer therapy field due to simultaneously combing the capabilities of therapeutic and diagnostic methods into a single nanoprobe.
METHOD
METHODS
In this study, we developed a theranostic probe based on superparamagnetic iron oxide (SPIO) and bismuth oxide (Bi
RESULT
RESULTS
The GQDs-Fe/Bi nanocomposites showed strong light absorbance profile with wide-band in the near-infrared region, without any sharp peak or decline. The highest photo-to-thermal conversion efficacy (η), was found to be 31.8% with the high photostability upon the irradiation of NIR 808-nm laser. The results of in vitro photothermal ablation of cancerous cells demonstrated that the cells significantly killed in the presence of NPs (∼53.4%) with a dose-dependent manner in comparison to only laser group (3.0%). In GQDs-Fe/Bi nanocomposites, Bi with a high atomic number (Z = 83) exhibited a superior X-ray attenuation capability (175%) than the clinical CT agent-used dotarem, also, SPIO with excellent magnetization property showed strong T
CONCLUSION
CONCLUSIONS
Our results demonstrate that the developed NPs can incorporate dual-modality imaging capability into a photo absorber for CT/MR imaging-guided tumor PTT.
Identifiants
pubmed: 30385298
pii: S1572-1000(18)30257-6
doi: 10.1016/j.pdpdt.2018.10.021
pii:
doi:
Substances chimiques
Ferric Compounds
0
ferric oxide
1K09F3G675
Graphite
7782-42-5
bismuth oxide
A6I4E79QF1
Bismuth
U015TT5I8H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
504-514Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.