Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer.
immunotherapy
regulatory T cell
tumor immunology
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
19
09
2018
revised:
10
10
2018
accepted:
26
10
2018
pubmed:
6
11
2018
medline:
10
7
2019
entrez:
3
11
2018
Statut:
ppublish
Résumé
The role of aldehyde dehydrogenase (ALDH) in carcinogenesis and resistance to cancer therapies is well known. Mounting evidence also suggests a potentially important role for ALDH in the induction and function of regulatory T (Treg) cells. Treg cells are important cells of the immune system involved in promoting immune tolerance and preventing aberrant immune responses to beneficial or non-harmful antigens. However, Treg cells also impair tumor immunity, leading to the progression of various carcinomas. ALDH expression and the subsequent production of retinoic acid by numerous cells, including dendritic cells, macrophages, eosinophils and epithelial cells, seems important in Treg induction and function in multiple organ systems. This is particularly evident in the gastrointestinal tract, pulmonary tract and skin, which are exposed to a myriad of environmental antigens and represent interfaces between the human body and the outside world. Expression of ALDH in Treg cells themselves may also be involved in the proliferation of these cells and resistance to certain cytotoxic therapies. Hence, inhibition of ALDH expression may be useful to treat cancer. Besides the direct effect of ALDH inhibition on carcinogenesis and resistance to cancer therapies, inhibition of ALDH could potentially augment the immune response to tumor antigens by inhibiting Treg induction, function and ability to promote immune tolerance to tumor cells in multiple cancer types.
Identifiants
pubmed: 30387499
doi: 10.1111/imm.13016
pmc: PMC6283653
doi:
Substances chimiques
Aldehyde Dehydrogenase
EC 1.2.1.3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-55Informations de copyright
© 2018 John Wiley & Sons Ltd.
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