Botulinum and Tetanus Neurotoxins.
bacterial toxin
botulinum neurotoxin
clostridium
protein engineering
tetanus neurotoxin
toxin
Journal
Annual review of biochemistry
ISSN: 1545-4509
Titre abrégé: Annu Rev Biochem
Pays: United States
ID NLM: 2985150R
Informations de publication
Date de publication:
20 06 2019
20 06 2019
Historique:
pubmed:
6
11
2018
medline:
1
7
2020
entrez:
3
11
2018
Statut:
ppublish
Résumé
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.
Identifiants
pubmed: 30388027
doi: 10.1146/annurev-biochem-013118-111654
pmc: PMC7539302
mid: NIHMS1633607
doi:
Substances chimiques
Tetanus Toxin
0
tetanospasmin
11032-48-7
Metalloendopeptidases
EC 3.4.24.-
Botulinum Toxins
EC 3.4.24.69
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
811-837Subventions
Organisme : NINDS NIH HHS
ID : R21 NS106159
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080833
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132387
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD018655
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
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