Biomarkers in abnormal uterine bleeding†.
Adenomyosis
/ complications
Anovulation
/ complications
Biomarkers
/ analysis
Blood Coagulation Disorders
/ complications
Female
Humans
Leiomyoma
/ complications
Menorrhagia
/ diagnosis
Metrorrhagia
/ diagnosis
Polyps
/ diagnosis
Precision Medicine
Uterine Diseases
/ complications
Uterine Hemorrhage
/ classification
Uterine Neoplasms
/ complications
angiogenesis
apoptosis
endometrium
epigenetics
estradiol/estradiol receptor
female reproductive tract
menstrual cycle
progesterone/progesterone receptor
proteomics
uterus
Journal
Biology of reproduction
ISSN: 1529-7268
Titre abrégé: Biol Reprod
Pays: United States
ID NLM: 0207224
Informations de publication
Date de publication:
24 12 2019
24 12 2019
Historique:
accepted:
31
10
2018
received:
21
07
2018
revised:
23
10
2018
pubmed:
6
11
2018
medline:
4
9
2020
entrez:
3
11
2018
Statut:
ppublish
Résumé
Abnormal uterine bleeding (AUB) is an extremely common problem and represents a clinical area of unmet need. It has clinical implications and a high cost for the healthcare system. The PALM-COEIN acronym proposed by FIGO may be used as a foundation of care; it improves the understanding of the causes of AUB, and in doing so facilitates effective history taking, examination, investigations, and management. Heavy menstrual bleeding, a subset of AUB, is a subjective diagnosis and should be managed in the context of improving the woman's quality of life. Available evidence suggests that there is poor satisfaction with standard treatment options often resulting in women opting for major surgery such as hysterectomy. Such women would benefit from a tailored approach, both for diagnosis and treatment, highlighting the deficiency of biomarkers in this area. This article focuses on the causes of AUB as per the PALM-COEIN acronym, the researched biomarkers in this area, and the potential pathogenetic mechanisms. In the future, these approaches may improve our understanding of AUB, thereby enabling us to direct women to most suitable current treatments and tailor investigative and treatment strategies to ensure best outcomes, in keeping with the principles of personalized or precision medicine.
Identifiants
pubmed: 30388215
pii: 5154908
doi: 10.1093/biolre/ioy231
pmc: PMC6931000
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1155-1166Subventions
Organisme : Medical Research Council
ID : G0600048
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N022556/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0500047
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0000066
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J003611/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction.
Références
Magn Reson Med Sci. 2019 Jan 10;18(1):82-87
pubmed: 29343660
J Clin Endocrinol Metab. 2011 Feb;96(2):412-21
pubmed: 21084396
J Reprod Fertil. 1999 Mar;115(2):389-95
pubmed: 10434946
Ann N Y Acad Sci. 2004 Dec;1034:50-63
pubmed: 15731299
Reprod Sci. 2017 Jan;24(1):28-46
pubmed: 27189201
Reproduction. 2001 Jan;121(1):3-19
pubmed: 11226025
Abdom Radiol (NY). 2018 Jun;43(6):1456-1463
pubmed: 28952003
Pathol Int. 2014 Mar;64(3):115-22
pubmed: 24698421
Semin Reprod Med. 2010 May;28(3):169-79
pubmed: 20414841
Endocrinology. 2013 Aug;154(8):2900-11
pubmed: 23720426
J Clin Endocrinol Metab. 2004 Nov;89(11):5549-57
pubmed: 15531510
Mol Cell Endocrinol. 2011 Mar 15;335(1):42-51
pubmed: 20723578
Cancer Sci. 2008 Mar;99(3):510-7
pubmed: 18201275
Nat Rev Mol Cell Biol. 2009 Apr;10(4):276-86
pubmed: 19305417
Ann N Y Acad Sci. 2008 Apr;1127:101-5
pubmed: 18443336
Nature. 2004 Aug 26;430(7003):1034-9
pubmed: 15329723
Best Pract Res Clin Obstet Gynaecol. 2017 Apr;40:82-88
pubmed: 27784616
Obstet Gynecol. 1956 Feb;7(2):206-10
pubmed: 13288977
Ultrasound Obstet Gynecol. 2015 Sep;46(3):284-98
pubmed: 25652685
J Minim Invasive Gynecol. 2018 Feb;25(2):257-264
pubmed: 28864044
J Clin Endocrinol Metab. 1999 Jan;84(1):240-8
pubmed: 9920091
Gynecol Obstet Invest. 2006;62(4):229-35
pubmed: 16837781
Fertil Steril. 2009 Aug;92(2):828.e11-2
pubmed: 19524890
Eur J Gynaecol Oncol. 2000;21(2):180-3
pubmed: 10843481
Hum Reprod. 1999 Dec;14(12):3095-100
pubmed: 10601102
Trends Immunol. 2004 Jun;25(6):280-8
pubmed: 15145317
Hum Reprod. 2007 Apr;22(4):945-52
pubmed: 17208943
J Clin Endocrinol Metab. 1999 Jul;84(7):2563-7
pubmed: 10404837
Best Pract Res Clin Obstet Gynaecol. 2017 Apr;40:68-81
pubmed: 27810281
Reprod Sci. 2018 Apr;25(4):498-514
pubmed: 29320956
Am J Obstet Gynecol. 1993 Sep;169(3):734-8
pubmed: 8372890
J Reprod Med. 2014 Jan-Feb;59(1-2):20-4
pubmed: 24597282
Thromb Haemost. 2001 Dec;86(6):1353-9
pubmed: 11776298
Methods. 2014 Nov;70(1):46-58
pubmed: 25242720
Hum Reprod. 2014 Mar;29(3):473-9
pubmed: 24408315
N Biotechnol. 2012 Sep 15;29(6):625-33
pubmed: 23091837
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6373-8
pubmed: 15849270
Mol Cell Proteomics. 2012 Jul;11(7):M112.017988
pubmed: 22493182
Int J Gynecol Pathol. 2009 Mar;28(2):157-63
pubmed: 19188818
Nat Commun. 2018 Jan 23;9(1):295
pubmed: 29362355
Eur J Obstet Gynecol Reprod Biol. 2014 Feb;173:88-93
pubmed: 24365097
Hum Reprod. 2014 May;29(5):964-77
pubmed: 24622619
Eur J Obstet Gynecol Reprod Biol. 1999 Jan;82(1):73-6
pubmed: 10192489
Fertil Steril. 2011 Mar 1;95(3):1164-7
pubmed: 20970134
Eur J Obstet Gynecol Reprod Biol. 1996 Dec;70(1):15-7
pubmed: 9031912
Vascul Pharmacol. 2016 Dec;87:242-247
pubmed: 27865826
AJP Rep. 2016 Mar;6(1):e6-e14
pubmed: 26929872
Endocrinology. 2017 Mar 1;158(3):592-603
pubmed: 27967206
Obstet Gynecol Clin North Am. 2011 Dec;38(4):703-31
pubmed: 22134018
Gynecol Obstet Invest. 1983;16(3):129-35
pubmed: 6618283
Hum Reprod. 2006 Oct;21(10):2545-54
pubmed: 16763009
Postgrad Med J. 2009 Oct;85(1008):538-45
pubmed: 19789193
Sci Rep. 2017 Dec 12;7(1):17416
pubmed: 29234102
Obstet Gynecol. 2000 May;95(5):688-91
pubmed: 10775730
Mol Hum Reprod. 2004 Sep;10(9):655-63
pubmed: 15243126
Curr Opin Obstet Gynecol. 2007 Dec;19(6):591-5
pubmed: 18007139
J Pathol. 2010 Nov;222(3):261-70
pubmed: 20814901
Hum Reprod. 2011 Feb;26(2):337-45
pubmed: 21115504
Semin Reprod Med. 2011 Sep;29(5):383-90
pubmed: 22065325
Br J Obstet Gynaecol. 1993 Aug;100(8):768-71
pubmed: 8399019
Fertil Steril. 2008 Dec;90(6):2269-80
pubmed: 18258230
Biomaterials. 2011 Feb;32(5):1396-403
pubmed: 21093044
Ultrasound Obstet Gynecol. 2009 Jan;33(1):102-8
pubmed: 19115236
Ultrasound Obstet Gynecol. 2014 Apr;43(4):372-82
pubmed: 23996650
Fertil Steril. 2012 Jul;98(1):11-20
pubmed: 22657248
Fertil Steril. 2016 Sep 15;106(4):967-77
pubmed: 27553264
Fertil Steril. 2005 Nov;84(5):1345-51
pubmed: 16275228
Mol Cell Endocrinol. 1994 Jul;103(1-2):165-70
pubmed: 7958393
Science. 2011 Oct 14;334(6053):252-5
pubmed: 21868628
Environ Mol Mutagen. 2008 Apr;49(3):226-31
pubmed: 18288718
Am J Reprod Immunol. 2013 Oct;70(4):327-35
pubmed: 23614810
Hum Reprod Update. 1996 Jul-Aug;2(4):295-306
pubmed: 9080227
Int J Gynaecol Obstet. 2011 Apr;113(1):3-13
pubmed: 21345435
Gynecol Obstet Invest. 1997;44(3):200-5
pubmed: 9359649
Hum Reprod. 2016 Apr;31(4):734-49
pubmed: 26908845
J Minim Invasive Gynecol. 2013 Sep-Oct;20(5):562-72
pubmed: 23680518
Immunity. 2010 May 28;32(5):593-604
pubmed: 20510870
Am J Obstet Gynecol. 2003 Jan;188(1):100-7
pubmed: 12548202
Fertil Steril. 2009 Sep;92(3):886-9
pubmed: 19296948
J Clin Endocrinol Metab. 2008 Sep;93(9):3490-8
pubmed: 18559911
J Clin Endocrinol Metab. 2018 Nov 1;103(11):4283-4292
pubmed: 30099503
Am J Pathol. 2009 Aug;175(2):479-88
pubmed: 19608877
Ultrasound Obstet Gynecol. 2019 May;53(5):576-582
pubmed: 29790217
Hum Reprod. 1999 Apr;14(4):1072-9
pubmed: 10221243
Am J Obstet Gynecol. 2012 Mar;206(3):211.e1-9
pubmed: 22244472
Fertil Steril. 2013 Jun;99(7):1951-7
pubmed: 23498888
J Clin Endocrinol Metab. 2011 Aug;96(8):2475-83
pubmed: 21677035
Arch Gynecol Obstet. 2015 Apr;291(4):917-32
pubmed: 25241270
Hum Mutat. 2012 May;33(5):777-80
pubmed: 22504886
Biol Reprod. 2009 Sep;81(3):545-52
pubmed: 19403928
Obstet Gynecol. 2003 Mar;101(3):431-7
pubmed: 12636944
Stem Cell Res Ther. 2017 Jan 23;8(1):9
pubmed: 28115012
Int J Gynaecol Obstet. 2019 Feb;144(2):237
pubmed: 30609040
Ultraschall Med. 2016 Aug;37(4):373-8
pubmed: 26274380
Antonie Van Leeuwenhoek. 2018 Jun;111(6):933-943
pubmed: 29299770
Fertil Steril. 2014 Jan;101(1):242-7
pubmed: 24314919
J Reprod Immunol. 2015 Nov;112:88-94
pubmed: 26398782
Am J Reprod Immunol. 2007 May;57(5):361-6
pubmed: 17430500
Annu Rev Immunol. 2000;18:621-63
pubmed: 10837071
Asian Pac J Trop Med. 2014 Feb;7(2):149-52
pubmed: 24461530
J Am Assoc Gynecol Laparosc. 1998 Nov;5(4):375-8
pubmed: 9782141
Mol Hum Reprod. 1997 Aug;3(8):685-91
pubmed: 9294852
Arch Gynecol Obstet. 2013 Jul;288(1):201-5
pubmed: 23371435
Endocrinology. 2006 Feb;147(2):744-53
pubmed: 16282352
Acta Obstet Gynecol Scand. 1966;45(3):320-51
pubmed: 5922481
Womens Health (Lond). 2012 May;8(3):301-12
pubmed: 22554177
Am J Reprod Immunol. 2002 Apr;47(4):251-5
pubmed: 12069392
Fertil Steril. 2013 Mar 15;99(4):1086-92
pubmed: 23043689
Hum Reprod Update. 2015 Nov-Dec;21(6):748-61
pubmed: 26253932
Oncogene. 1999 Nov 22;18(49):6910-24
pubmed: 10602466
Hum Reprod Update. 1998 Sep-Oct;4(5):509-19
pubmed: 10027603
Am J Med. 2008 Jun;121(6):501-508.e3
pubmed: 18501231
BJOG. 2004 Jul;111(7):734-40
pubmed: 15198765
Fertil Steril. 2010 Jul;94(2):701-7
pubmed: 19406397
Cochrane Database Syst Rev. 2007 Oct 17;(4):CD003449
pubmed: 17943792
Hum Reprod. 2013 May;28(5):1324-38
pubmed: 23442759
Mol Hum Reprod. 2015 Apr;21(4):330-8
pubmed: 25542836
Endocr Rev. 2005 Feb;26(1):44-62
pubmed: 15689572
Acta Obstet Gynecol Scand. 2010 Nov;89(11):1374-84
pubmed: 20932128
Arch Gynecol Obstet. 2011 Apr;283(4):775-80
pubmed: 21079983
BMC Womens Health. 2018 Aug 22;18(1):142
pubmed: 30134884