Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.

Adipogenesis Animals Animals, Newborn Bone and Bones / cytology Femur / abnormalities Gene Expression Regulation Growth Plate / abnormalities Mesenchymal Stem Cells / metabolism Mice, Inbred C57BL Osteoblasts / cytology Polycomb Repressive Complex 1 / genetics Tibia / abnormalities
Adipocyte Bone marrow Growth Polycomb

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
03 2019
Historique:
received: 19 03 2018
revised: 19 10 2018
accepted: 19 10 2018
pubmed: 6 11 2018
medline: 20 2 2020
entrez: 4 11 2018
Statut: ppublish

Résumé

A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which cell lineage and gene sets are targeted by polycomb proteins during skeletal growth. We now report that mice deficient in a polycomb group gene Cbx2

Identifiants

DOI: 10.1016/j.bone.2018.10.021 PMID: 30389610
pubmed: 30389610
pii: S8756-3282(18)30401-0
doi: 10.1016/j.bone.2018.10.021
pii:
doi:

Substances chimiques

Cbx2 protein, mouse 0
Polycomb Repressive Complex 1 EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

219-231

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Yuko Katoh-Fukui (Y)

Department of Molecular Endocrinology, National Research Institute of Child Health and Development, Tokyo 157-8535, Japan. Electronic address: fukui-y@ncchd.go.jp.

Takashi Baba (T)

Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Systems Life Sciences, Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.

Tetsuya Sato (T)

Department of Systems Life Sciences, Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan; Division of Bioinformatics, Kyushu University, Fukuoka, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka, Japan.

Hiroyuki Otake (H)

Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Yuko Nagakui-Noguchi (Y)

The National Center for Geriatrics and Gerontology, Aichi, Japan.

Miyuki Shindo (M)

Department of Experimental Animals, National Research Institute of Child Health and Development, Tokyo, Japan.

Mikita Suyama (M)

Department of Systems Life Sciences, Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan; Division of Bioinformatics, Kyushu University, Fukuoka, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka, Japan.

Yasuyuki Ohkawa (Y)

Department of Systems Life Sciences, Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka, Japan; Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Hideki Tsumura (H)

Department of Experimental Animals, National Research Institute of Child Health and Development, Tokyo, Japan.

Ken-Ichirou Morohashi (KI)

Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Systems Life Sciences, Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.

Maki Fukami (M)

Department of Molecular Endocrinology, National Research Institute of Child Health and Development, Tokyo 157-8535, Japan.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adipogenèse › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Appareil locomoteur › Squelette › Os du membre inférieur › Fémur › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Appareil locomoteur › Squelette › Épiphyses (os) › Lame épiphysaire › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-1 › Mouse polycomb group gene Cbx2 promotes...
questionsmedicales.fr › Appareil locomoteur › Squelette › Os du membre inférieur › Os de la jambe › Tibia › Mouse polycomb group gene Cbx2 promotes...