Effects of Topically Administered Neuroprotective Drugs in Early Stages of Diabetic Retinopathy: Results of the EUROCONDOR Clinical Trial.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
19
06
2018
accepted:
21
10
2018
pubmed:
6
11
2018
medline:
6
8
2019
entrez:
4
11
2018
Statut:
ppublish
Résumé
The primary objective of this study was to assess whether the topical administration of two neuroprotective drugs (brimonidine and somatostatin) could prevent or arrest retinal neurodysfunction in patients with type 2 diabetes. For this purpose, adults aged between 45 and 75 years with a diabetes duration ≥5 years and an Early Treatment of Diabetic Retinopathy Study (ETDRS) level of ≤35 were randomly assigned to one of three arms: placebo, somatostatin, or brimonidine. The primary outcome was the change in implicit time (IT) assessed by multifocal electroretinography between baseline and at the end of follow-up (96 weeks). There were 449 eligible patients allocated to brimonidine (
Identifiants
pubmed: 30389750
pii: db18-0682
doi: 10.2337/db18-0682
doi:
Substances chimiques
Neuroprotective Agents
0
Brimonidine Tartrate
4S9CL2DY2H
Somatostatin
51110-01-1
Types de publication
Clinical Trial, Phase II
Clinical Trial, Phase III
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
457-463Investigateurs
R Simó
(R)
C Hernández
(C)
M García-Ramírez
(M)
E van Reck
(E)
E Gil
(E)
M Morillas
(M)
J Cunha-Vaz
(J)
L Ribeiro
(L)
C Lobo
(C)
M A Costa
(MA)
S Nunes
(S)
J Figueira
(J)
I Pereira-Marques
(I)
C Neves
(C)
C Schwartz
(C)
M Porta
(M)
M Trento
(M)
O Durando
(O)
S Merlo
(S)
F Bandello
(F)
R Lattanzio
(R)
I Zucchiatti
(I)
J Grauslund
(J)
U Frydkjaer-Olsen
(U)
S P Harding
(SP)
P Scanlon
(P)
S J Aldington
(SJ)
V Jones
(V)
L Johnson
(L)
S Carter
(S)
J Spurway
(J)
C Egan
(C)
S Esposti
(S)
L Leitch-Devlin
(L)
V Rocco
(V)
A Rees
(A)
J García-Arumí
(J)
M A Zapata
(MA)
A Boixadera
(A)
C Macià
(C)
L Distefano
(L)
T Torrent
(T)
F Casals
(F)
N de Dios
(N)
J Gibson
(J)
G E Lang
(GE)
W Jens-Ulrich
(W)
E Christian
(E)
K Adnan
(K)
P Massin
(P)
A Erginay
(A)
E Midena
(E)
S Vujosevic
(S)
E Pilotto
(E)
E Longhin
(E)
E Convento
(E)
B Ponsati
(B)
J Fernández-Carneado
(J)
S Arrastia-Casado
(S)
S Orgué
(S)
D T Ramírez-Lamelas
(DT)
A Almazán-Moga
(A)
A Salvà
(A)
L Riera
(L)
Informations de copyright
© 2018 by the American Diabetes Association.