Limited short-term effects on human prostate cancer xenograft growth and epidermal growth factor receptor gene expression by the ghrelin receptor antagonist [D-Lys

Animals Cell Proliferation / drug effects ErbB Receptors / genetics Gene Expression / drug effects Heterografts Humans Male Mice Mice, Inbred NOD Mice, SCID Oligopeptides / pharmacology PC-3 Cells Prostatic Neoplasms / genetics Receptors, Ghrelin / antagonists & inhibitors
Ghrelin Ghrelin receptor antagonist PC3 Prostate cancer Xenograft [D-Lys3]-GHRP-6

Journal

Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444

Informations de publication

Date de publication:
05 2019
Historique:
received: 20 06 2018
accepted: 17 10 2018
pubmed: 6 11 2018
medline: 12 5 2020
entrez: 4 11 2018
Statut: ppublish

Résumé

The ghrelin axis regulates many physiological functions (including appetite, metabolism, and energy balance) and plays a role in disease processes. As ghrelin stimulates prostate cancer proliferation, the ghrelin receptor antagonist [D-Lys NOD/SCID mice with PC3 prostate cancer xenografts were administered 20 nmoles/mouse [D-Lys We demonstrate here that daily intraperitoneal injection of 20 nmoles/mouse [D-Lys We show that [D-Lys

Identifiants

DOI: 10.1007/s12020-018-1796-9 PMID: 30390209
pubmed: 30390209
doi: 10.1007/s12020-018-1796-9
pii: 10.1007/s12020-018-1796-9
doi:

Substances chimiques

Oligopeptides 0
Receptors, Ghrelin 0
growth hormone releasing hexapeptide 4H7N4I6X6A
ErbB Receptors EC 2.7.10.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

393-405

Subventions

Organisme : National Health and Medical Research Council Australia
ID : 1059021
Pays : International
Organisme : Cancer Council Queensland
ID : 1098565
Pays : International
Organisme : Australian Research Council (AU)
ID : DP140100249
Pays : International

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Auteurs

Michelle L Maugham (ML)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Skeletal Biology and Forensic Anthropology Research Laboratory, Cancer Program, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Inge Seim (I)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Integrative Biology Laboratory, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.

Patrick B Thomas (PB)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Gabrielle J Crisp (GJ)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Esha T Shah (ET)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Adrian C Herington (AC)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Laura S Gregory (LS)

Skeletal Biology and Forensic Anthropology Research Laboratory, Cancer Program, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Colleen C Nelson (CC)

Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Penny L Jeffery (PL)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

Lisa K Chopin (LK)

Ghrelin Research Group, Institute of Health and Biomedical Innovation, Translational Research Institute and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia. l.chopin@qut.edu.au.
Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia. l.chopin@qut.edu.au.
Comparative and Endocrine Biology Laboratory, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia. l.chopin@qut.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Limited short-term effects on human prostate...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Limited short-term effects on human prostate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › Limited short-term effects on human prostate...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Limited short-term effects on human prostate...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Limited short-term effects on human prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Limited short-term effects on human prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Limited short-term effects on human prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Limited short-term effects on human prostate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Limited short-term effects on human prostate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Limited short-term effects on human prostate...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules PC-3 › Limited short-term effects on human prostate...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Limited short-term effects on human prostate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs à la ghréline › Limited short-term effects on human prostate...