CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia.
CAR T cells
CD7
acute myeloid leukemia
chimeric antigen receptors
mouse model
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
12
03
2018
revised:
26
09
2018
accepted:
01
10
2018
pubmed:
6
11
2018
medline:
18
12
2019
entrez:
5
11
2018
Statut:
ppublish
Résumé
Chimeric antigen receptor (CAR) T cell therapy for the treatment of acute myeloid leukemia (AML) has the risk of toxicity to normal myeloid cells. CD7 is expressed by the leukemic blasts and malignant progenitor cells of approximately 30% of AML patients but is absent on normal myeloid and erythroid cells. Since CD7 expression by malignant blasts is also linked with chemoresistance and poor outcomes, targeting this antigen may be beneficial for this subset of AML patients. Here, we show that expression of a CD7-directed CAR in CD7 gene-edited (CD7
Identifiants
pubmed: 30391141
pii: S1525-0016(18)30490-8
doi: 10.1016/j.ymthe.2018.10.001
pmc: PMC6318703
pii:
doi:
Substances chimiques
Antigens, CD7
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
272-280Subventions
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA126752
Pays : United States
Informations de copyright
Copyright © 2018 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.
Références
Proc Natl Acad Sci U S A. 1980 May;77(5):2914-8
pubmed: 6156457
Br J Haematol. 1989 Dec;73(4):480-5
pubmed: 2482063
Nat Med. 1997 Jul;3(7):730-7
pubmed: 9212098
Blood. 2017 Jul 20;130(3):285-296
pubmed: 28539325
Blood. 2013 Oct 31;122(18):3138-48
pubmed: 24030378
Leukemia. 2018 May;32(5):1168-1179
pubmed: 29472720
Leuk Res. 2009 Feb;33(2):326-31
pubmed: 18718658
J Exp Med. 1993 Jun 1;177(6):1531-9
pubmed: 7684429
Leukemia. 2018 Sep;32(9):1970-1983
pubmed: 29483708
J Exp Med. 2007 Dec 24;204(13):3085-93
pubmed: 18070935
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Blood. 1993 May 1;81(9):2399-405
pubmed: 7683218
Cell. 2018 May 31;173(6):1439-1453.e19
pubmed: 29856956
Leukemia. 2019 Jan;33(1):64-74
pubmed: 29946192
Mol Ther. 2013 Nov;21(11):2122-9
pubmed: 23831595
Leuk Lymphoma. 1995 Mar;17(1-2):111-9
pubmed: 7539657
Cell Rep. 2016 Oct 25;17(5):1453-1461
pubmed: 27783956
Lancet. 2015 Feb 7;385(9967):517-528
pubmed: 25319501
Br J Haematol. 2001 Dec;115(3):612-5
pubmed: 11736944
Blood. 2014 Apr 10;123(15):2343-54
pubmed: 24596416
Sci Transl Med. 2013 Mar 20;5(177):177ra38
pubmed: 23515080
Nat Immunol. 2010 Jul;11(7):585-93
pubmed: 20543838
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19051-6
pubmed: 16365285
Blood Adv. 2017 Nov 21;1(25):2348-2360
pubmed: 29296885
Leuk Res. 2004 Jan;28(1):43-8
pubmed: 14630079
Immunity. 1995 Oct;3(4):459-73
pubmed: 7584137
Blood. 2013 Nov 14;122(20):3461-72
pubmed: 24016461
J Clin Oncol. 2015 Feb 20;33(6):540-9
pubmed: 25154820
Nat Immunol. 2012 Oct;13(10):963-71
pubmed: 22941246
Blood. 2015 May 28;125(22):3466-76
pubmed: 25887778
Mol Ther. 2015 Jan;23(1):184-91
pubmed: 25174587
Blood. 2015 Aug 20;126(8):983-92
pubmed: 26056165
Am J Hematol. 1998 Aug;58(4):278-84
pubmed: 9692390
Cancer Cell. 2011 Jan 18;19(1):138-52
pubmed: 21251617
Nat Biotechnol. 2007 Nov;25(11):1315-21
pubmed: 17952057
Blood. 2002 Dec 1;100(12):3887-96
pubmed: 12393641
Leuk Res. 2007 Feb;31(2):157-62
pubmed: 16837044
Best Pract Res Clin Haematol. 2016 Dec;29(4):329-333
pubmed: 27890255
J Immunol. 1994 Jan 15;152(2):517-26
pubmed: 7506726
Cancer Cell. 2017 Oct 9;32(4):506-519.e5
pubmed: 29017060
Cell Stem Cell. 2007 Dec 13;1(6):635-45
pubmed: 18371405
Leukemia. 2015 Aug;29(8):1637-47
pubmed: 25721896
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5009-14
pubmed: 21383193
Blood. 2001 Jun 15;97(12):3683-90
pubmed: 11389003
Mol Ther. 2017 Sep 6;25(9):2202-2213
pubmed: 28676343