High-flow versus standard nasal cannula in morbidly obese patients during colonoscopy: A prospective, randomized clinical trial.
Aged
Cannula
Colonoscopy
/ adverse effects
Deep Sedation
/ adverse effects
Female
Humans
Hypoxia
/ etiology
Male
Middle Aged
Noninvasive Ventilation
/ instrumentation
Obesity, Morbid
/ complications
Oxygen
/ analysis
Pain, Procedural
/ prevention & control
Propofol
/ administration & dosage
Prospective Studies
Treatment Outcome
Colonoscopy
Deep sedation
High-flow nasal cannula
Morbid obesity
Journal
Journal of clinical anesthesia
ISSN: 1873-4529
Titre abrégé: J Clin Anesth
Pays: United States
ID NLM: 8812166
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
22
07
2018
revised:
01
10
2018
accepted:
28
10
2018
pubmed:
6
11
2018
medline:
11
7
2019
entrez:
5
11
2018
Statut:
ppublish
Résumé
Morbid obesity is associated with adverse airway events including desaturation during deep sedation. Prior works have suggested that proprietary high-flow nasal cannula devices generate positive pressure to all airway structures and may be superior to standard (low-flow) nasal cannula for prevention of desaturation. We hypothesized that, at a similar fraction of inspired oxygen (FiO This is a pragmatic, prospective, randomized clinical trial at one hospital (NCT03148262, UTSW#112016-058). Morbidly obese patients were randomized to HFNC during propofol sedation for colonoscopy. HFNC was performed using maximum flow rates of 60 liters per minute (LPM) and FiO Patients were randomized to HFNC (n = 28) or SNC (n = 31). Interim analysis of the primary endpoint showed that the desaturation rates in the HFNC group (39.3%) and the SNC group (45.2%) were not significantly different (p = 0.79). The DMC halted the trial at that point due to futility. At similar FiO
Identifiants
pubmed: 30391445
pii: S0952-8180(18)30969-3
doi: 10.1016/j.jclinane.2018.10.026
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Propofol
YI7VU623SF
Types de publication
Comparative Study
Journal Article
Pragmatic Clinical Trial
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-24Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.