A 1-Day, 90-Minute Aspirin Challenge and Desensitization Protocol in Aspirin-Exacerbated Respiratory Disease.
Aspirin
/ administration & dosage
Asthma, Aspirin-Induced
/ etiology
Chronic Disease
Cyclooxygenase Inhibitors
/ administration & dosage
Desensitization, Immunologic
/ methods
Dose-Response Relationship, Drug
Female
Forced Expiratory Volume
Humans
Male
Middle Aged
Nasal Polyps
/ chemically induced
Rhinitis
/ chemically induced
Sinusitis
/ chemically induced
AERD
Aspirin challenge
Aspirin desensitization
Aspirin-exacerbated respiratory disease
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
23
08
2018
revised:
02
10
2018
accepted:
17
10
2018
pubmed:
6
11
2018
medline:
25
7
2020
entrez:
5
11
2018
Statut:
ppublish
Résumé
Aspirin challenge and desensitization remains the criterion standard in diagnosis and treatment for patients with aspirin-exacerbated respiratory disease (AERD), but the protocols can be time and resource intensive. To provide evidence that oral aspirin challenge and desensitization can be safely performed in an outpatient setting in 1 day. Forty-four patients with a confirmed diagnosis of AERD, stable asthma, and baseline FEV Ninety-three percent of patients completed the challenge and desensitization in 1 day, with an average protocol completion time of 9 hours and 29 minutes. Two patients (4.6%) chose to complete the protocol over 2 days. One patient (2.3%) was discontinued from the protocol because of ongoing abdominal discomfort and diarrhea. No patient required epinephrine, emergency department visit, or hospitalization. Patients with AERD on a stable asthma regimen and with a baseline FEV
Sections du résumé
BACKGROUND
Aspirin challenge and desensitization remains the criterion standard in diagnosis and treatment for patients with aspirin-exacerbated respiratory disease (AERD), but the protocols can be time and resource intensive.
OBJECTIVE
To provide evidence that oral aspirin challenge and desensitization can be safely performed in an outpatient setting in 1 day.
METHODS
Forty-four patients with a confirmed diagnosis of AERD, stable asthma, and baseline FEV
RESULTS
Ninety-three percent of patients completed the challenge and desensitization in 1 day, with an average protocol completion time of 9 hours and 29 minutes. Two patients (4.6%) chose to complete the protocol over 2 days. One patient (2.3%) was discontinued from the protocol because of ongoing abdominal discomfort and diarrhea. No patient required epinephrine, emergency department visit, or hospitalization.
CONCLUSIONS
Patients with AERD on a stable asthma regimen and with a baseline FEV
Identifiants
pubmed: 30391549
pii: S2213-2198(18)30703-7
doi: 10.1016/j.jaip.2018.10.032
pmc: PMC6456426
mid: NIHMS1515230
pii:
doi:
Substances chimiques
Cyclooxygenase Inhibitors
0
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1174-1180Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL128241
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007306
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI095219
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL111113
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI118804
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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