Multigenerational effects of dietary macronutrient intake on the metabolic phenotype of male Wistar rats.
Diet
Dietary macronutrients
Metabolic syndrome
Phenotype
Journal
Nutrition (Burbank, Los Angeles County, Calif.)
ISSN: 1873-1244
Titre abrégé: Nutrition
Pays: United States
ID NLM: 8802712
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
11
2017
revised:
10
06
2018
accepted:
21
06
2018
pubmed:
6
11
2018
medline:
23
1
2020
entrez:
5
11
2018
Statut:
ppublish
Résumé
Gene-nutrient interactions are implicated in metabolic phenotypes like metabolic syndrome. The aim of this study was to examine the effects of diet-induced metabolic phenotypes in rats and investigate the effects of these phenotypes in three successive generations. Three generations of rats were fed on different diets and mated. Blood glucose, adiposity, lipid profile, insulin, adipocytokines, ghrelin, and corticosterone concentrations were determined in F0, F1, and F2 generations using standard methods. In comparison with control across generations, glucose (32%), triacylglycerols (52%), and insulin (10%) were significantly elevated in the high-fat diet (HFD)-fed rats; total cholesterol was higher in HFD and high-carbohydrate diet (HCD)-fed groups; whereas high density lipoprotein was higher in the HFD rats but lower in the HPD rats. Adipocytokines were significantly higher in the HCD and HFD groups but lower in the high-protein diet group, whereas ghrelin only declined in HFD rats. This study revealed that different dietary macronutrients induced distinctive metabolic phenotypes, which had variable effects in different generations.
Identifiants
pubmed: 30391691
pii: S0899-9007(18)30606-3
doi: 10.1016/j.nut.2018.06.008
pii:
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-133Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.